US4058511A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tegretol antigens and antibodies
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1976-01-12
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Granted: 1977-11-15
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Expires: 1996-01-12
Abstract
Abstract Derivatives of dibenz[b,f]azepine drugs are provided for preparation of antigens and antibodies, the antibodies finding use in immunoassays for the dibenz[b,f]azepine drugs. Specifically, N-oxoaliphatic substituted carbamoyl dibenz[b,f]azepine compounds are provided which are conjugated with antigenic materials and injected into animals for production of antibodies specific for the azepine drug.
Inventors
- 👤 Prithipal Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:15
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/44; C07D; C07D223/00; C07D223/14; C07D223/18; C07D223/22; Y; Y10; Y10S; Y10S435/00; Y10S435/961; Y10S436/00; Y10S436/815; Y10S436/823; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
159 words
A compound of the formula: ##STR5## wherein: m is 0 or 1, R 1 is a bond or an aliphatic radical of from 1 to 8 carbon atoms having from 0 to 1 site of ethylenic unsaturation as the only unsaturation and from 0 to 1 heteroatom of atomic number 7 to 8 bonded solely to carbon with the proviso that R 1 has at least 2 carbon atoms when m is 0; Y 1 is an antigenic poly(amino acid) of at least 1,000 molecular weight; and n 1 is at least 1 and not greater than the molecular weight of Y 1 divided by 500, with the proviso that when m is OR 1 is bonded to amino groups of said poly(amino acid) by a single covalent bond to form an alkylamino and when m is 1 the carboxy carbonyl is bonded to amino groups of said poly(amino acid) by a single covalent bond to form an amide.
Claim 2
Dependent Claim
159 words
A compound of the formula: ##STR5## wherein: m is 0 or 1, R 1 is a bond or an aliphatic radical of from 1 to 8 carbon atoms having from 0 to 1 site of ethylenic unsaturation as the only unsaturation and from 0 to 1 heteroatom of atomic number 7 to 8 bonded solely to carbon with the proviso that R 1 has at least 2 carbon atoms when m is 0; Y 1 is an antigenic poly(amino acid) of at least 1,000 molecular weight; and n 1 is at least 1 and not greater than the molecular weight of Y 1 divided by 500, with the proviso that when m is OR 1 is bonded to amino groups of said poly(amino acid) by a single covalent bond to form an alkylamino and when m is 1 the carboxy carbonyl is bonded to amino groups of said poly(amino acid) by a single covalent bond to form an amide.
Claim 3
Dependent Claim
33 words
A compound according to claim 1, wherein Y 1 is of molecular weight in the range of about 10,000 to 500,000 and n 1 is in the range of about 4 to 250.
Claim 4
Dependent Claim
12 words
A compound according to claim 2, wherein Y 1 is an albumin.
Claim 5
Dependent Claim
12 words
A compound according to claim 2, wherein Y 1 is a globulin.
Claim 6
Dependent Claim
18 words
A compound according to claim 2, wherein R 1 is polymethylene of from 2 to 6 carbon atoms.
Claim 7
Dependent Claim
26 words
A compound according to claim 2 wherein Y 1 is an albumin or globulin, R 1 is polymethylene of 3 carbon atoms and m is 0.
Claim 8
Dependent Claim
25 words
A compound according to claim 2 wherein Y 1 is albumin or globulin, R 1 is polymethylene of 2 carbom atoms and m is 1.
Claim 9
Dependent Claim
25 words
A compound according to claim 2, wherein Y 1 is albumin or globulin, R 1 is polymethylene of 5 carbon atoms and m is 1.
Claim 10
Dependent Claim
11 words
Antibodies prepared in response to a compound according to claim 1.
Claim 11
Dependent Claim
11 words
Antibodies prepared in response to a compound according to claim 2.
Claim 12
Dependent Claim
11 words
Antibodies prepared in response to a compound according to claim 5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |