US4057685A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemically modified endotoxin immunizing agent
Assignee: Abbott Laboratories
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Filing: 1974-05-09
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Granted: 1977-11-08
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Expires: 1994-05-09
Abstract
Abstract A bacterial endotoxin lipopolysaccharide of reduced toxicity covalently coupled to a protein antigen exhibits enhanced adjuvant effects. The coupling was affected by reaction with haloacylhalide. Lipopolysaccharide acylated with an anhydride of a dibasic acid is detoxified; in combination with endotoxin polysaccharide covalently coupled to protein antigen it developed synergistic immunogenic effects.
Inventors
- 👤 Floyd Cottam McIntire
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:37
CPC Classifications
C; C08; C08B; C08B37/00; A; A61; A61K; A61K39/00; A61K39/385; A61K39/39; A61K2039/555; A61K2039/55511; A61K2039/55572; A61K2039/60; A61K2039/6087; Y; Y10; Y10S; Y10S530/00; Y10S530/807
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
79 words
A bacterial endotoxin derivative of reduced toxicity comprising a gram-negative bacterial lipoplysaccharide having at least one free amino group and an anhydride selected from the group consisting of compounds of the formula ##STR5## wherein n is 0 or 1, and R, R 1 and R 2 each represent hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 5 -C 6 cycloalkyl, phthalyl or methylphthalyl wherein any two R groups taken together form a saturated cyclic substituent.
Claim 2
Dependent Claim
79 words
A bacterial endotoxin derivative of reduced toxicity comprising a gram-negative bacterial lipoplysaccharide having at least one free amino group and an anhydride selected from the group consisting of compounds of the formula ##STR5## wherein n is 0 or 1, and R, R 1 and R 2 each represent hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 5 -C 6 cycloalkyl, phthalyl or methylphthalyl wherein any two R groups taken together form a saturated cyclic substituent.
Claim 3
Dependent Claim
23 words
The bacterial endotoxin derivative of claim 1 wherein the anhydride is selected from the group consisting of glutaryl, succinyl, phthalyl or methyl phthalyl.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |