US4057627A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acne preparation for oral administration
Assignee: Individual
•
Filing: 1975-06-18
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Granted: 1977-11-08
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Expires: 1995-06-18
Abstract
Abstract An acne preparation for oral administration and a method of preparing the same in which a nutrient medium, such as, meat-peptone broth is inoculated with Corynebacterium acnes, such as, Beck, Gerrath and Vogel strains and combinations thereof, fermentation is carried out, the Corynebacterium acnes are inactivated, preferably by treatment with ultrasonics, and freeze-dried, to form an immunizing constituent. This immunizing constituent is preferably mixed with metabolic products of Corynebacterium acnes as a desensitizing constituent, preferably antigens contained in the nutrient medium in which Corynebacterium acnes are cultivated. The composition may be made in the form of tablets, capsules or liquids, such as, emulsions or syrups, and may contain conventional adjuvants, carriers and/or auxiliary agents.
Inventors
- 👤 Helmut Anton Stickl
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 11:02
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/66; A61K35/74; A61K31/00; A61K31/13; A61K31/155; A61K39/00; A61K39/02; A61K39/05; A61K9/00; A61K9/0087; A61K9/0095; A61K9/20; A61K9/2004; A61K9/2013; A61K2039/51; A61K2039/52; A61K2039/521; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/843
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
19 words
An acne composition for oral administration, comprising inactivated Corynebacterium acnes as an immunizing constituent and a pharmaceutically-acceptable carrier therefor.
Claim 2
Dependent Claim
19 words
An acne composition for oral administration, comprising inactivated Corynebacterium acnes as an immunizing constituent and a pharmaceutically-acceptable carrier therefor.
Claim 3
Dependent Claim
28 words
The acne composition of claim 1, comprising metabolic products of Corynebacterium acnes, contained in the nutrient medium in which said Corynebacterium acnes are cultivated, as a desensitizing constituent.
Claim 4
Dependent Claim
27 words
A composition in accordance with claim 1 wherein the inactivated Corynebacterium acnes are selected from the group consisting of Gerrath, Beck and Vogel strains and combinations thereof.
Claim 5
Dependent Claim
12 words
The composition of claim 1 which additionally contains urea as an immuno-adjuvant.
Claim 6
Dependent Claim
13 words
The composition of claim 1, wherein the Corynebacterium acnes are in freeze-dried form.
Claim 7
Dependent Claim
18 words
The composition of claim 1 wherein the composition is in the form of a tablet, capsule, or liquid.
Claim 8
Dependent Claim
18 words
The theraputic composition of claim 1 in unit dosage form comprising at least 1 billion of Corynebacterium acnes.
Claim 9
Dependent Claim
15 words
A composition as defined in claim 7 in which the Corynebacterium acnes strain is Gerrath.
Claim 10
Dependent Claim
15 words
A composition as defined in claim 7 in which the Corynebacterium acnes strain is Vogel.
Claim 11
Dependent Claim
15 words
A composition as defined in claim 7 in which the Corynebacterium acnes strain is Beck.
Claim 12
Dependent Claim
30 words
The composition of claim 11, in which said Corynebacterium acnes are a combination of at least two Corynebacterium acnes strains selected from the group consisting of Beck, Gerrath and Vogel.
Claim 13
Dependent Claim
19 words
The composition of claim 11 wherein the strains Beck, Gerrath and Vogel are present in the ratios of 1-3:1-3:0.5-1.5.
Claim 14
Dependent Claim
19 words
The composition of claim 11 wherein the strains Beck, Gerrath and Vogel are present in the ratio of 2:2:1.
Claim 15
Dependent Claim
14 words
The composition of claim 7 in the form of a tablet, capsule, or liquid.
Claim 16
Dependent Claim
14 words
The composition of claim 7 wherein at least one of the components is lyophilized.
Claim 17
Dependent Claim
24 words
The composition of claim 7, which additionally includes metabolic products of Corynebacterium acnes from the culture medium in which said Corynebacterium acnes are cultivated.
Claim 18
Dependent Claim
22 words
A composition as defined in claim 16, wherein the metabolic product is an antigen-containing fraction of the culture medium of Corynebacterium acnes.
Claim 19
Dependent Claim
13 words
The composition in accordance with claim 7 which contains a non-toxic adjuvant material.
Claim 20
Dependent Claim
12 words
The composition of claim 7 which additionally contains urea as an immuno-adjuvant.
Claim 21
Dependent Claim
17 words
A composition in accordance with claim 1 wherein the composition is in the form of a liquid.
Claim 22
Dependent Claim
18 words
A method of treating acne infection in man by oral administration of a composition according to claim 1.
Claim 23
Dependent Claim
19 words
The method of treating acne infection in man according to claim 21 wherein urea is employed as an immuno-adjuvant.
Claim 24
Dependent Claim
18 words
A method of treating acne infection in man by oral administration of a composition according to claim 2.
Claim 25
Dependent Claim
61 words
A process for producing an acne composition for oral administration, comprising cultivating Corynebacterium acnes in a nutrient medium under anaerobic conditions until substantial growth of said Corynebacterium acnes has occurred, recovering said Corynebacterium acnes from said nutrient medium and mixing at least a portion of the metabolic products of said Corynebacterium acnes contained in said nutrient medium with said Corynebacterium acnes.
Claim 26
Dependent Claim
61 words
A process for producing an acne composition for oral administration, comprising cultivating Corynebacterium acnes in a nutrient medium under anaerobic conditions until substantial growth of said Corynebacterium acnes has occurred, recovering said Corynebacterium acnes from said nutrient medium and mixing at least a portion of the metabolic products of said Corynebacterium acnes contained in said nutrient medium with said Corynebacterium acnes.
Claim 27
Dependent Claim
28 words
A process in accordance with claim 24 wherein the metabolic products in Corynebacterium acnes are a mixture of said Corynebacterium acnes of the Gerrath, Beck and Vogel strains.
Claim 28
Dependent Claim
45 words
A process for producing an acne composition for oral administration, comprising cultivating Corynebacterium acnes in a nutrient medium under anaerobic conditions until substantial growth of said Corynebacterium acnes has occurred, recovering said Corynebacterium acnes from said nutrient medium and mixing urea with said Corynebacterium acnes.
Claim 29
Dependent Claim
45 words
A process for producing an acne composition for oral administration, comprising cultivating Corynebacterium acnes in a nutrient medium under anaerobic conditions until substantial growth of said Corynebacterium acnes has occurred, recovering said Corynebacterium acnes from said nutrient medium and mixing urea with said Corynebacterium acnes.
References Cited (Backward Citations)
US3651214A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |