US4054660A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of inhibiting prolactin
Assignee: Eli Lilly and Co
•
Filing: 1976-08-19
•
Granted: 1977-10-18
•
Expires: 1996-08-19
Abstract
Abstract D-2-halo-6-alkyl-8-substituted ergolines and related compounds are inhibitors of prolactin in mammals.
Inventors
- 👤 James A. Clemens
- 👤 Edmund C. Kornfeld
- 👤 Nicholas J. Bach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:30
CPC Classifications
C; C07; C07D; C07D457/00; C07D457/02
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
76 words
A process for inhibiting the secretion of prolactin in mammals which comprises administering from 0.01 to 10 mg/kg/day of mammalian weight of a compound of Formula II or a salt thereof formed with a pharmaceutically-acceptable acid, to a mammal having a condition in which there is an excess of prolactin being secreted: ##STR5## wherein X is Cl, Br or I, R is CH 2 --CN or ##STR6## and R' is C 1 -C 3 primary alkyl.
Claim 2
Dependent Claim
76 words
A process for inhibiting the secretion of prolactin in mammals which comprises administering from 0.01 to 10 mg/kg/day of mammalian weight of a compound of Formula II or a salt thereof formed with a pharmaceutically-acceptable acid, to a mammal having a condition in which there is an excess of prolactin being secreted: ##STR5## wherein X is Cl, Br or I, R is CH 2 --CN or ##STR6## and R' is C 1 -C 3 primary alkyl.
Claim 3
Dependent Claim
12 words
A process according to claim 1 in which D-2-chloro-6-methyl-8-cyanomethylergoline methanesulfonate is administered.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-17 | 1981-04-18 | 1981-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-17 | 1985-04-18 | 1985-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-17 | 1989-04-18 | 1989-10-18 | $7700.00 | Window Closed / Lapsed |