Patent US2221618A successfully refreshed from Google Patents.
US4052010A
Expired / Lapsed
US
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Suspendable porous glass particles
Assignee: Corning Glass Works
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Filing: 1974-03-01
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Granted: 1977-10-04
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Expires: 1994-03-01
Abstract
Abstract An aqueous suspension of porous glass particles having a closely controlled average particle size within the range of about 0.7 to about 3.0 microns. The controlled particle size porous glass particles are prepared by initially milling course porous glass particles to yield particles of about 10 microns or less, leaching those particles to remove contaminants and residues, rinsing the particles, and then mixing the particles with an aqueous solution and subjecting the mixture to at least two controlled sedimentation steps.
Inventors
- 👤 Frederick G. Baker
- 👤 David L. Eaton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:02
CPC Classifications
C; C03; C03C; C03C23/00; C03C23/008; A; A61; A61K; A61K39/00; A61K39/395; A61K39/44; C03C11/00; C03C12/00; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/551; G01N33/552; Y; Y10; Y10S; Y10S436/00; Y10S436/804
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
113 words
A method of preparing a suspension of porous glass particles of controlled particle size and useful as antibody carriers in solid phase radioimmunoassay comprising the steps of: A. milling controlled pore porous glass particles having an average pore diameter between about 100 A and 1200 A to an average particle size of less than about 10 microns; B. acid-washing the milled particles to remove contaminants and residues; C. washing the particles to remove any residues from step (B); D. mixing the washed particles with water to form a first suspension of the particles; E. subjecting the first suspension to a first sedimentation step to assure removal of particles greater than about 10 microns;
Claim 2
Independent Claim
113 words
A method of preparing a suspension of porous glass particles of controlled particle size and useful as antibody carriers in solid phase radioimmunoassay comprising the steps of: A. milling controlled pore porous glass particles having an average pore diameter between about 100 A and 1200 A to an average particle size of less than about 10 microns; B. acid-washing the milled particles to remove contaminants and residues; C. washing the particles to remove any residues from step (B); D. mixing the washed particles with water to form a first suspension of the particles; E. subjecting the first suspension to a first sedimentation step to assure removal of particles greater than about 10 microns;
Claim 3
Dependent Claim
38 words
F. subjecting the remaining first suspension to at least one more sedimentation step to sediment particles having an average particle size between about 0.7 and about 3.0 microns; and G. suspending the particles of step (F) in water.
Claim 4
Dependent Claim
38 words
F. subjecting the remaining first suspension to at least one more sedimentation step to sediment particles having an average particle size between about 0.7 and about 3.0 microns; and G. suspending the particles of step (F) in water.
Claim 5
Dependent Claim
26 words
The method of claim 1 wherein the porous glass particles of step (A) have an average pore diameter between about 485 A and about 920 A.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein the acid-washing of step (B) is with 0.8 N HCl solution.
Claim 7
Dependent Claim
21 words
The method of claim 1 wherein the suspension of step (G) is effected by sonicating the porous glass particles in water.
Claim 8
Dependent Claim
24 words
The method of claim 4 wherein the suspension consists of about 50 to about 150 mg of porous glass particles per ml of water.
Claim 9
Dependent Claim
23 words
The method of claim 5 wherein the porous glass particles have an average particle size between about 0.7 microns and about 1.7 microns.
Claim 10
Dependent Claim
22 words
The method of claim 1 wherein the porous glass particles have a surface area of at least about 20 m 2 /g.
Claim 11
Dependent Claim
25 words
The method of claim 1 wherein the sedimentation of step (E) is accomplished by centrifugation at a relative centrifuge force range of 20 to 80.
Claim 12
Dependent Claim
25 words
The method of claim 1 wherein the sedimentation of steo (F) is accomplished by centrifugation at a relative centrifuge force range of 5,000 to 10,000.
Claim 13
Dependent Claim
45 words
The method of claim 1 wherein the sedimentation of step (E) is accomplished by centrifugation at a relative centrifuge force range of 20 to 80 and the sedimentation of step (F) is accomplished by centrifugation at a relative centrifuge force range of 5,000 to 10,000.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-03 | 1981-04-04 | 1981-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-03 | 1985-04-04 | 1985-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-03 | 1989-04-04 | 1989-10-04 | $7700.00 | Window Closed / Lapsed |