Patent US2187217A successfully refreshed from Google Patents.
US4049827A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating arrhythmia with diarylbutanolamines
Assignee: Eli Lilly and Co
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Filing: 1976-10-12
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Granted: 1977-09-20
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Expires: 1996-10-12
Abstract
Abstract 4,4-Diphenyl-2-hydroxybutylamines are prepared by condensing amines with 1,2-epoxy-4,4-diphenylbutanes. The new compounds exist in the free base form, as acid addition salts and quaternary ammonium salts, and exhibit antiarrhythmic activity.
Inventors
- 👤 Bryan Barnet Molloy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:47
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07D303/00; C07D303/02; C07D303/04; C07D303/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
130 words
A method of treating arrhythmia which comprises administering to a subject suffering from an arrhythmia and in need of treatment or to a subject suspected of developing an arrhythmia an amount effective for treating the arrhythmia of a compound of the formula ##STR2## wherein: X is hydrogen or fluorine; R 1 is hydrogen or C 1 -C 3 alkyl; R 2 and R 3 independently are hydrogen, C 1 -C 6 alkyl, or --CH 2 R 4 , wherein R 4 is C 2 -C 5 alkenyl; or R 2 and R 3 taken together with the adjacent nitrogen atom to which they are attached complete a heterocyclic ring selected from pyrrolidine, piperidine, morpholine, or methyl and dimethyl substituted pyrrolidine, piperidine and morpholine; and the non-toxic pharmaceutically acceptable salts thereof.
Claim 2
Independent Claim
130 words
A method of treating arrhythmia which comprises administering to a subject suffering from an arrhythmia and in need of treatment or to a subject suspected of developing an arrhythmia an amount effective for treating the arrhythmia of a compound of the formula ##STR2## wherein: X is hydrogen or fluorine; R 1 is hydrogen or C 1 -C 3 alkyl; R 2 and R 3 independently are hydrogen, C 1 -C 6 alkyl, or --CH 2 R 4 , wherein R 4 is C 2 -C 5 alkenyl; or R 2 and R 3 taken together with the adjacent nitrogen atom to which they are attached complete a heterocyclic ring selected from pyrrolidine, piperidine, morpholine, or methyl and dimethyl substituted pyrrolidine, piperidine and morpholine; and the non-toxic pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
18 words
The method according to claim 1 wherein in the compound being administered, R 1 is other than hydrogen.
Claim 4
Dependent Claim
16 words
The method according to claim 2 wherein in the compound being administered, R 1 is methyl.
Claim 5
Dependent Claim
16 words
The method according to claim 1 wherein in the compound being administered, R 1 is hydrogen.
Claim 6
Dependent Claim
19 words
The method according to claim 4 wherein the compound administered is N-isopropyl-4,4-diphenyl-2-hydroxybutylamine or a non-toxic pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
13 words
The method according to claim 5 wherein the compound administered is N-isopropyl-4,4-diphenyl-2-hydroxybutylaminium chloride.
Claim 8
Dependent Claim
12 words
The method according to claim 1 wherein the compound is administered orally.
Claim 9
Dependent Claim
12 words
The method according to claim 1 wherein the compound is administered parenterally.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-19 | 1981-03-21 | 1981-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-19 | 1985-03-21 | 1985-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-19 | 1989-03-21 | 1989-09-20 | $7700.00 | Window Closed / Lapsed |