US4048325A
Expired / Lapsed
US
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Low toxicity method of inhibiting sickling of sickle erythrocytes
Assignee: Energy Research and Development Administration ERDA
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Filing: 1976-01-05
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Granted: 1977-09-13
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Expires: 1996-01-05
Abstract
Abstract A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.
Inventors
- 👤 Lester Packer
- 👤 Edwin N. Bymun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:08
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
59 words
A method of inhibiting sickling of human sickle erythrocytes which comprises intermixing the erythrocytes with a water-soluble monofunctional imidoester having the general formula RC(═NH)OR' wherein R is an alkyl group of 1-8 carbon atoms and R' is an alkyl group of 1-4 carbon atoms in a amount effective to inhibit sickling and below the toxicity level of the imidoester.
Claim 2
Independent Claim
59 words
A method of inhibiting sickling of human sickle erythrocytes which comprises intermixing the erythrocytes with a water-soluble monofunctional imidoester having the general formula RC(═NH)OR' wherein R is an alkyl group of 1-8 carbon atoms and R' is an alkyl group of 1-4 carbon atoms in a amount effective to inhibit sickling and below the toxicity level of the imidoester.
Claim 3
Dependent Claim
19 words
A method according to claim 1 wherein the intermixing of the erthrocytes and the mono-functional imidoester is accomplished extracorporeally.
Claim 4
Dependent Claim
17 words
A method according to claim 1 wherein R is an alkyl group of 1- 4 carbon atoms.
Claim 5
Dependent Claim
14 words
A method according to claim 3 wherein R' is a methyl or ethyl group.
Claim 6
Dependent Claim
11 words
A method according to claim 4 wherein the imidoester is ethylacetimidate.
Claim 7
Dependent Claim
11 words
A method according to claim 4 wherein the imidoester is methylacetimidate.
Claim 8
Dependent Claim
11 words
A method according to claim 4 wherein the imidoester is methylbutyrimidate.
Claim 9
Dependent Claim
33 words
A method according to claim 1 wherein the amount of imidoester is equivalent to a concentration of imidoester in whole blood in the range of from about 1 mM to about 10 mM.
Claim 10
Dependent Claim
31 words
A method according to claim 8 wherein the amount of imidoester is equivalent to a concentration in whole blood in the range of from about 2 mM to about 5 mM.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-12 | 1981-03-14 | 1981-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-12 | 1985-03-14 | 1985-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-12 | 1989-03-14 | 1989-09-13 | $7700.00 | Window Closed / Lapsed |