US4043905A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chromatographic separation columns with selectively modified active surfaces and methods for their preparations
Assignee: Indiana University Foundation Inc
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Filing: 1974-08-26
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Granted: 1977-08-23
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Expires: 1994-08-26
Abstract
Abstract Selective monomolecular layers on siliceous surfaces used for the construction of high-resolution chromatographic columns are prepared by surface reactions with monohalogenated silanes, silazanes or silylamines, or monoalkoxy- or monoacetoxysilanes, and subsequent chemical modifications. Such monolayers form a basis for efficient films of chemically compatible stationary phases by introducing selective groups in gas-liquid chromatography and all forms of liquid chromatography, or for adsorbent modifications in gas-solid chromatography.
Inventors
- 👤 Milos V Novotny
- 👤 Karel Grohmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:13
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/02; B01J20/10; B01J20/103; B01J20/28; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/30; B01J20/3078; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/3261; B01J2220/00; B01J2220/50; B01J2220/54; B01J2220/58; B01J2220/80; B01J2220/84; B01J2220/86
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
29 words
A method of preparing chromotographic columns comprising active surfaces fabricated of a siliceous material which method includes the step of modifying said surfaces by reaction with chlorodimethyl (4-(4-chloromethylphenyl)butyl) silane.
Claim 2
Independent Claim
29 words
A method of preparing chromotographic columns comprising active surfaces fabricated of a siliceous material which method includes the step of modifying said surfaces by reaction with chlorodimethyl (4-(4-chloromethylphenyl)butyl) silane.
Claim 3
Dependent Claim
50 words
A method according to claim 1 wherein the reaction is effected by heating for at least 30 minutes while the chlorodimethyl (4-(4-chloromethylphenyl) butyl silane and surface are in contact and is followed by flushing of the surface with solvents of different polarities and drying at a temperature above 41° C.
Claim 4
Dependent Claim
25 words
A method according to claim 2 including the further step of coating said surface with a solution to form a stationary phase for chromatographic separation.
Claim 5
Dependent Claim
36 words
A chromatographic column comprising active surfaces fabricated of siliceous material carrying a monomolecular layer thereon mechanically and chemically compatible with a stationary phase to be applied thereto, said layer being formed of chlorodimethyl (4-(4-chloromethylphenyl) butyl silane.
Claim 6
Dependent Claim
36 words
A chromatographic column comprising active surfaces fabricated of siliceous material carrying a monomolecular layer thereon mechanically and chemically compatible with a stationary phase to be applied thereto, said layer being formed of chlorodimethyl (4-(4-chloromethylphenyl) butyl silane.
References Cited (Backward Citations)
US3116161A
Cited
US3666530A
Cited
US3922392A
Cited
US3869409A
Cited
US3808125A
Cited
US3954651A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-22 | 1981-02-21 | 1981-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-22 | 1985-02-21 | 1985-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-22 | 1989-02-21 | 1989-08-23 | $7700.00 | Window Closed / Lapsed |