US4041173A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Carboxy-(7-,8- and 9-substituted)-5-oxo-5H-dibenzo (a,d) cycloheptenes and the corresponding 10,11-dihydro compounds
Assignee: Syntex USA LLC
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Filing: 1975-10-06
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Granted: 1977-08-09
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Expires: 1995-10-06
Abstract
Abstract A compound selected from the group of compounds represented by the formula <IMAGE> R is hydrogen, alkyl having 1 to 12 carbon atoms, or <IMAGE> where n is an integer of 2 to 4 inclusive and R4 and R5 are independently lower alkyl of 1 to 6 carbon atoms inclusive or together R4 and R5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 to 6 total ring atoms; R1 is at the 7, 8 or 9 position and is halogen, hydroxy, lower alkoxy of 1 to 6 carbon atoms inclusive, or lower alkyl of 1 to 4 carbons atoms, inclusive; THE DOTTED LINES MAY BE AN ADDITIONAL, OPTIONAL BOND BETWEEN THE CARBON ATOMS AT THE 10- AND 11 POSITIONS; AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. The compounds are used pharmaceutically to treat allergic reactions and autoimmune diseases.
Inventors
- 👤 Peter H. Nelson
- 👤 Karl G. Untch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:31
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/54; C07F9/5456; C07C; C07C51/00; C07C51/41; C07C51/412; C07C63/00; C07C63/68; C07C63/72; C07C65/00; C07C65/21; C07C65/24; C07C65/32; C07C65/34; C07C65/36; C07C65/40
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
79 words
A compound selected from the group of compounds represented by the formula ##STR15## R is hydrogen or alkyl having one to twelve carbon atoms; R 1 is at the 7, 8 or 9 position and is halogen, hydroxy, lower alkoxy of 1 to 6 carbon atoms inclusive or lower alkyl of 1 to 4 carbon atoms, inclusive; the dotted lines represent an additional bond between the carbon atoms at the 10- and 11-positions; and the pharmaceutical acceptable salts thereof.
Claim 2
Dependent Claim
79 words
A compound selected from the group of compounds represented by the formula ##STR15## R is hydrogen or alkyl having one to twelve carbon atoms; R 1 is at the 7, 8 or 9 position and is halogen, hydroxy, lower alkoxy of 1 to 6 carbon atoms inclusive or lower alkyl of 1 to 4 carbon atoms, inclusive; the dotted lines represent an additional bond between the carbon atoms at the 10- and 11-positions; and the pharmaceutical acceptable salts thereof.
Claim 3
Dependent Claim
28 words
The compound of claim 1 wherein R 1 is fluoro at the 9 position and the bond between the carbons at 10- and 11- is a double bond.
Claim 4
Dependent Claim
29 words
The compound of claim 1 wherein R 1 is a chloro at the 9 position and the bond between the carbons at 10- and 11- is a double bond.
Claim 5
Dependent Claim
28 words
The compound of claim 1 wherein R 1 is bromo at the 9 position and the bond between the carbons at 10- and 11- is a double bond.
Claim 6
Dependent Claim
60 words
A compound selected from the group of compounds represented by the formula ##STR16## R is hydrogen or alkyl having 1 to 12 carbon atoms; R 1 is fluoro, chloro or bromo at the 9 position; alkyl of 1, 2 or 3 carbon atoms at the 7- or 9-position; or isopropoxy at the 7 position; and the pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
60 words
A compound selected from the group of compounds represented by the formula ##STR16## R is hydrogen or alkyl having 1 to 12 carbon atoms; R 1 is fluoro, chloro or bromo at the 9 position; alkyl of 1, 2 or 3 carbon atoms at the 7- or 9-position; or isopropoxy at the 7 position; and the pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
14 words
The compound of claim 5 wherein R 1 is fluoro at the 9 position.
Claim 9
Dependent Claim
14 words
The compound of claim 5 wherein R 1 is chloro at the 9 position.
Claim 10
Dependent Claim
14 words
The compound of claim 5 wherein R 1 is bromo at the 9 position.
Claim 11
Dependent Claim
14 words
The compound of claim 5 wherein R 1 is methyl at the 9 position.
Claim 12
Dependent Claim
14 words
The compound of claim 5 wherein R 1 is isopropyl at the 9 position.
Claim 13
Dependent Claim
14 words
The compound of claim 5 wherein R 1 is isopropyl at the 7 position.
Claim 14
Dependent Claim
34 words
A process for treatment of an asthmatic condition in an animal which comprises administering by inhalation to said animal an amount of the compound of claim 5 effective for relief of said asthmatic condition.
Claim 15
Dependent Claim
34 words
A pharmaceutical composition useful for treatment of an asthmatic condition which comprises a suitable pharmaceutical excipient and a compound of claim 5 present in an amount sufficient to give relief of said asthmatic condition.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-08 | 1981-02-07 | 1981-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-08 | 1985-02-07 | 1985-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-08 | 1989-02-07 | 1989-08-09 | $7700.00 | Window Closed / Lapsed |