US4039685A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-phenoxy-2-hydroxy-3-tert.-butylamino propane antiarrhythmic compounds
Assignee: Boehringer Ingelheim GmbH
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Filing: 1975-04-25
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Granted: 1977-08-02
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Expires: 1995-04-25
Abstract
Abstract A compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula ##STR1## wherein R is selected from the group consisting of alkynyloxy of 2 to 4 carbon atoms, and R 1 is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 4 carbon atoms, their optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts of said racemates and said optically active isomers which compounds possess bradycardia activity and isoproterenol antagonistic activity and also antiarrhythmic activity.
Inventors
- 👤 Herbert Koppe
- 👤 Albrecht Engelhardt
- 👤 Karl Zeile
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:40
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/14; A61K31/275; A61K31/33; A61K31/395; A61K31/495; A61K31/505
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
65 words
A compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula ##STR6## where R is alkynyloxy of 2 to 4 carbon atoms, R 1 is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 4 carbon atoms, their optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts of said racemates and said optically active isomers.
Claim 2
Dependent Claim
65 words
A compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula ##STR6## where R is alkynyloxy of 2 to 4 carbon atoms, R 1 is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 4 carbon atoms, their optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts of said racemates and said optically active isomers.
Claim 3
Dependent Claim
10 words
A compound of claim 1 wherein R 1 is hydrogen.
Claim 4
Dependent Claim
23 words
A compound of claim 1 which is selected from the group consisting of 1-(2-propargyloxyphenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
26 words
A therapeutic composition having antiarrhythmic acitivity comprising a safe and effective amount of a compound of claim 1 and a major amount of a pharmaceutical carrier.
Claim 6
Dependent Claim
24 words
A method of inducing antiarrhythmic acitivity in warm-blooded animals comprising administering to warm-blooded animals an antiarrhythmically effective amount of a compound of claim 1.
Claim 7
Dependent Claim
25 words
The method of claim 5 wherein the compound is selected from the group consisting of 1-(2-propargyloxyphenoxy)-2-hydroxy-3-tert.-butylamino propane and its non-toxic, pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |