US4039589A
Expired / Lapsed
US
⏱️ 0.0 years remaining
α-Substituted benzhydrol derivatives and a process for the preparation thereof
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
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Filing: 1974-08-08
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Granted: 1977-08-02
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Expires: 1994-08-08
Abstract
Abstract A compound of the formula: <IMAGE> wherein Z is ethyl or vinyl, R1 and R2 are hydrogen, lower alkyl, lower alkenyl or trihalomethyl, R3 and R4 are hydrogen, lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl or phenyl, and R5 is lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl, or phenyl with the proviso that where R1, R2, R3 and R4 each is hydrogen, R5 is not methyl attached to the 4-position of the benzene ring, or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof is disclosed as effective in the regulation of the liver microsomal enzyme system.
Inventors
- 👤 Edit Toth
- 👤 Jozsef Torley
- 👤 Szabolcs Szeberenyi
- 👤 Eva Palosi
- 👤 Laszlo Szporny
- 👤 Sandor Gorog
- 👤 Csilla Meszaros
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 21:10
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12; C07D295/135; A; A61; A61P; A61P1/00; A61P1/16; C07C; C07C255/00; C07C29/00; C07C29/36; C07C29/38; C07C29/40; C07C323/00; C07C41/00; C07C41/01; C07C41/18; C07C41/30; C07C65/00; C07C65/01
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
87 words
A compound of the formula: ##STR10## wherein Z is ethyl, R 1 , r 2 and R 3 , are hydrogen, R 4 is hydrogen, lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl or phenyl, and R 5 is lower alkyl or provided that where R 1 , R 2 , R 3 and R 4 each is hydrogen, R 5 is not methyl attached to the 4-position of the benzene ring, or a pharmaceutically acceptable acid addition or quaternary ammonium salt of the compound of said formula.
Claim 2
Dependent Claim
87 words
A compound of the formula: ##STR10## wherein Z is ethyl, R 1 , r 2 and R 3 , are hydrogen, R 4 is hydrogen, lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl or phenyl, and R 5 is lower alkyl or provided that where R 1 , R 2 , R 3 and R 4 each is hydrogen, R 5 is not methyl attached to the 4-position of the benzene ring, or a pharmaceutically acceptable acid addition or quaternary ammonium salt of the compound of said formula.
Claim 3
Dependent Claim
21 words
A compound selected from the group which consists of: 4-Phenyl-α-ethyl-benzhydrol, 4-Cyclopentyl-α-ethyl-benzhydrol, 2-Methyl-α-ethyl-benzhydrol, 4-Benzyl-α-ethyl-benzhydrol, 3-Trifluoromethyl-α-ethyl-benzhydrol, 2-Trifluoromethyl-α-ethyl-benzhydrol, 4-Trifluoromethyl-α-ethyl-benzhydrol, 4-n-Butyl-α-vinyl-benzhydrol, 4-tert.Butyl-α-ethyl-benzhydrol, 2,5-Dimethyl-α-ethyl-benzhydrol, and 4-n-Butyl-α-ethyl-benzhydrol
Claim 4
Dependent Claim
21 words
A compound selected from the group which consists of: 4-Phenyl-α-ethyl-benzhydrol, 4-Cyclopentyl-α-ethyl-benzhydrol, 2-Methyl-α-ethyl-benzhydrol, 4-Benzyl-α-ethyl-benzhydrol, 3-Trifluoromethyl-α-ethyl-benzhydrol, 2-Trifluoromethyl-α-ethyl-benzhydrol, 4-Trifluoromethyl-α-ethyl-benzhydrol, 4-n-Butyl-α-vinyl-benzhydrol, 4-tert.Butyl-α-ethyl-benzhydrol, 2,5-Dimethyl-α-ethyl-benzhydrol, and 4-n-Butyl-α-ethyl-benzhydrol
Claim 5
Dependent Claim
15 words
A compound of the following formula: ##STR11## wherein R is trihalomethyl and Z is ethyl.
Claim 6
Dependent Claim
15 words
A compound of the following formula: ##STR11## wherein R is trihalomethyl and Z is ethyl.
Claim 7
Dependent Claim
2 words
3-trifluoromethyl-α-ethyl benzhydrol.
Claim 8
Dependent Claim
2 words
3-trifluoromethyl-α-ethyl benzhydrol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |