US4039546A
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US
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Method of preparing N1 -(2'-furanidyl)-5-substituted uracils
Assignee: Individual
•
Filing: 1975-04-28
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Granted: 1977-08-02
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Expires: 1995-04-28
Abstract
Abstract A method of preparing N 1 -(2'-furanidyl)-substituted uracils having the general formula ##STR1## where R is selected from the group consisting of hydrogen, halogen, and alkyl, consists in that 2,3-dihydrofuran is processed with anhydrous hydrogen chloride in a medium of an organic chlorinated aliphatic hydrocarbon solvent, and the thus formed product is reacted with 2,4-bis-(trimethylsilyloxy)-5R-substituted pyrimidines at a temperature not above 10° C with subsequent isolation of the end product.
Inventors
- 👤 Solomon Aronovich Giller
- 👤 Arvid Avgustovich Lazdinsh
- 👤 Artur Karlovich Veinberg
- 👤 Alexandr Borisovich Sidorov
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:59
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/04
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
86 words
A method for preparing N 1 -(2'-furanidyl)-5-substituted uracils having the general formula ##STR4## where R is selected from the group consisting of hydrogen, halogens, and methyl which comprises the steps of reacting a 2,4-bis(trimethylsilyloxy)-5 R-substituted pyrimidine where R is as above, with a solution of 2,3-dihydrofuran in an organic chlorinated lower aliphatic hydrocarbon solvent which solution is being saturated with anhydrous hydrogen chloride, said reaction being conducted at a temperature below about 10° C., and the reaction product is then isolated by precipitation with an alkanol.
Claim 2
Independent Claim
86 words
A method for preparing N 1 -(2'-furanidyl)-5-substituted uracils having the general formula ##STR4## where R is selected from the group consisting of hydrogen, halogens, and methyl which comprises the steps of reacting a 2,4-bis(trimethylsilyloxy)-5 R-substituted pyrimidine where R is as above, with a solution of 2,3-dihydrofuran in an organic chlorinated lower aliphatic hydrocarbon solvent which solution is being saturated with anhydrous hydrogen chloride, said reaction being conducted at a temperature below about 10° C., and the reaction product is then isolated by precipitation with an alkanol.
Claim 3
Dependent Claim
20 words
The method according to claim 1, wherein said solvent is selected from the group consisting of dichloroethane, chloroform, and dichloromethane.
Claim 4
Dependent Claim
20 words
The method according to claim 1, wherein the process is carried out at a temperature from -5° to +5° C.
References Cited (Backward Citations)
US3912734A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |