US4038480A
Expired / Lapsed
US
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6-aminocarbonyl purine 3',5'-cyclic nucleotides
Assignee: Viratek Inc
•
Filing: 1973-09-17
•
Granted: 1977-07-26
•
Expires: 1993-09-17
Abstract
Abstract N 6 -Carbamoyl and -carbonyl analogs of adenosine 3',5'-cyclic phosphate (cAMP) are prepared and variously demonstrated to exhibit kinase, adrenal steroidogenisis and lipolysis activation superior to cAMP, inhibit phosphodiesterase, and found to increase cardiac output or, in particular cases, to lower blood pressure.
Inventors
- 👤 Roland K. Robins
- 👤 Dennis A. Shuman
- 👤 Kay H. Boswell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:44
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; C07H19/20
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
62 words
A compound of structure ##STR3## wherein Y is COOR 1 , CONHR 1 , or CONHC 6 H 5 , X is C 1 -C 18 acyl, Y or H, Z is H, bromine, or chlorine SR 2 , R 1 is C 1 - C 6 alkyl and R 2 is H, phenyl, benzyl or C 1 - C 6 alkyl.
Claim 2
Dependent Claim
62 words
A compound of structure ##STR3## wherein Y is COOR 1 , CONHR 1 , or CONHC 6 H 5 , X is C 1 -C 18 acyl, Y or H, Z is H, bromine, or chlorine SR 2 , R 1 is C 1 - C 6 alkyl and R 2 is H, phenyl, benzyl or C 1 - C 6 alkyl.
Claim 3
Dependent Claim
12 words
A compound according to claim 1 wherein X is acyl or H.
Claim 4
Dependent Claim
17 words
A compound according to claim 2 wherein Y is CONHR 1 or CONHC 6 H 5 .
Claim 5
Dependent Claim
14 words
A compound according to claim 3 wherein Y is CONHC 6 H 5 .
Claim 6
Dependent Claim
6 words
N 6 -(N-methylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 7
Dependent Claim
6 words
N 6 -(N-methylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 8
Dependent Claim
6 words
N 6 -(N-propylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 9
Dependent Claim
6 words
N 6 -(N-propylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 10
Dependent Claim
6 words
N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 11
Dependent Claim
6 words
N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 12
Dependent Claim
6 words
N 6 -(ethoxycarbonyl) adenosine 3',5'-cyclic phosphate.
Claim 13
Dependent Claim
6 words
N 6 -(ethoxycarbonyl) adenosine 3',5'-cyclic phosphate.
Claim 14
Dependent Claim
6 words
8-Benzylthio-N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 15
Dependent Claim
6 words
8-Benzylthio-N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 16
Dependent Claim
6 words
8-Benzylthio-2'-O-butyryl-N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 17
Dependent Claim
6 words
8-Benzylthio-2'-O-butyryl-N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 18
Dependent Claim
6 words
2'-O-butyryl-N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 19
Dependent Claim
6 words
2'-O-butyryl-N 6 -(N-phenylcarbamoyl) adenosine 3',5'-cyclic phosphate.
Claim 20
Dependent Claim
58 words
A compound of the formula ##STR4## wherein Y is selected from the group consisting of COOR 1 , CONHR 1 and CONHC 6 H 5 ; X is selected from the group consisting of COOR 1 , CONHR 1 , CONHC 6 H 5 , C 1 -C 4 acyl and H and R 1 is lower alkyl.
Claim 21
Dependent Claim
58 words
A compound of the formula ##STR4## wherein Y is selected from the group consisting of COOR 1 , CONHR 1 and CONHC 6 H 5 ; X is selected from the group consisting of COOR 1 , CONHR 1 , CONHC 6 H 5 , C 1 -C 4 acyl and H and R 1 is lower alkyl.
Claim 22
Dependent Claim
12 words
A compound according to claim 12 wherein X is acyl or H.
Claim 23
Dependent Claim
10 words
A compound according to claim 12 wherein X is H.
Claim 24
Dependent Claim
12 words
A compound according to claim 13 wherein Y is CONHR 1 .
Claim 25
Dependent Claim
14 words
A compound according to claim 13 wherein Y is CONHC 6 H 5 .
Claim 26
Dependent Claim
15 words
A compound according to claim 15 wherein R 1 is C 1 -C 3 alkyl.
Claim 27
Dependent Claim
15 words
A compound according to claim 16 wherein R 1 is C 1 -C 3 alkyl.
Claim 28
Dependent Claim
12 words
A compound according to claim 14 wherein Y is CONHR 1 .
Claim 29
Dependent Claim
14 words
A compound according to claim 14 wherein Y is CONHC 6 H 5 .
Claim 30
Dependent Claim
15 words
A compound according to claim 15 wherein R 1 is C 1 -C 3 alkyl.
Claim 31
Dependent Claim
15 words
A compound according to claim 16 wherein R 1 is C 1 -C 3 alkyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-25 | 1981-01-24 | 1981-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-25 | 1985-01-24 | 1985-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-25 | 1989-01-24 | 1989-07-26 | $7700.00 | Window Closed / Lapsed |