US4038389A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medroxyprogesterone acetate compositions
Assignee: Pharmacia and Upjohn Co
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Filing: 1976-03-29
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Granted: 1977-07-26
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Expires: 1996-03-29
Abstract
Abstract A pharmaceutical vehicle for parenteral administration of medroxyprogesterone acetate is disclosed comprising an aqueous solution of sodium sulfate, quaternary ammonium wetting agent, and a member selected from glycerin, propylene glycol, polyethylene glycol, and polypropylene glycol. The compositions may contain a non-ionic hydrophilic colloid as a preferred adjuvant. Compositions are useful for suspending large amounts, e.g., from 200 to 600 mg./ml. of medroxyprogesterone acetate and maintaining suitable suspendability and syringeability characteristics and are used for the known therapeutic indications for medroxyprogesterone acetate.
Inventors
- 👤 Donald J. Lamb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:35
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K31/00; A61K31/56; A61K31/57; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/16; A61K47/18; A61K47/186
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
72 words
An aqueous suspension for parenteral administration comprising from about 200 to about 600 mg./ml. of suspended medroxyprogesterone acetate; water; from about 0.8% w/v to about 1.5% w/v of sodium sulfate; from about 0.1% w/v to about 1.4% w/v of a parenterally acceptable quaternary ammonium wetting agent; and from about 2% w/v to about 5% w/v of a member selected from the group consisting of glycerin, propylene glycol, polyethylene glycol and polypropylene glycol.
Claim 2
Dependent Claim
72 words
An aqueous suspension for parenteral administration comprising from about 200 to about 600 mg./ml. of suspended medroxyprogesterone acetate; water; from about 0.8% w/v to about 1.5% w/v of sodium sulfate; from about 0.1% w/v to about 1.4% w/v of a parenterally acceptable quaternary ammonium wetting agent; and from about 2% w/v to about 5% w/v of a member selected from the group consisting of glycerin, propylene glycol, polyethylene glycol and polypropylene glycol.
Claim 3
Dependent Claim
20 words
The composition of claim 1 additionally containing a parenterally acceptable non-ionic hydrophilic colloid in a concentration not exceeding 1.5% w/v.
Claim 4
Dependent Claim
25 words
The composition of claim 1 wherein the suspended medroxyprogesterone acetate is a fineness of 99% less than 10 microns and 75% less than 5 microns.
Claim 5
Dependent Claim
20 words
The composition of claim 3 additionally containing a parenterally acceptable non-ionic hydrophilic colloid in a concentration not exceeding 1.5% w/v.
References Cited (Backward Citations)
US3147290A
Cited
US3008875A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-25 | 1981-01-24 | 1981-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-25 | 1985-01-24 | 1985-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-25 | 1989-01-24 | 1989-07-26 | $7700.00 | Window Closed / Lapsed |