US4038282A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyridyl-4-methyl-succinimidocarbonate and process for its preparation
Assignee: Merck and Co Inc
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Filing: 1976-06-14
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Granted: 1977-07-26
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Expires: 1996-06-14
Abstract
Abstract The disclosed invention relates to ε-N-pyridyl-4-methyloxycarbonyllysine valuable in the synthesis of lysine containing peptides to the process of preparing this compound starting with 4-pyridyl-carbinol and succinimido-chloroformate and to the pyridyl-4-methyl-succinimidocarbonate intermediate in this process.
Inventors
- 👤 Ralph F. Hirschmann
- 👤 Daniel F. Veber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 11:02
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/06; C07K1/061; C07K1/064; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/28
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
68 words
The process which comprises reacting 4-pyridylcarbinol with succinimido-chloroformate, said reaction being carried out in substantially anhydrous ethyl acetate or halogenated hydrocarbon solvent while maintaining the temperature within the range of about -20° C. to 0° C., adding a tertiary amine to the solution, and maintaining the resulting solution at a temperature of about 0° C. to 5° C. for a period of about 15 minutes, thereby forming pyridyl-4-methyl-succinimidocarbonate.
Claim 2
Dependent Claim
68 words
The process which comprises reacting 4-pyridylcarbinol with succinimido-chloroformate, said reaction being carried out in substantially anhydrous ethyl acetate or halogenated hydrocarbon solvent while maintaining the temperature within the range of about -20° C. to 0° C., adding a tertiary amine to the solution, and maintaining the resulting solution at a temperature of about 0° C. to 5° C. for a period of about 15 minutes, thereby forming pyridyl-4-methyl-succinimidocarbonate.
Claim 3
Dependent Claim
1 words
Pyridyl-4-methyl-succinimidocarbonate.
Claim 4
Dependent Claim
1 words
Pyridyl-4-methyl-succinimidocarbonate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-25 | 1981-01-24 | 1981-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-25 | 1985-01-24 | 1985-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-25 | 1989-01-24 | 1989-07-26 | $7700.00 | Window Closed / Lapsed |