US4038222A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Untriakontapeptide with opiate activity
Assignee: University of California Berkeley
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Filing: 1976-03-17
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Granted: 1977-07-26
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Expires: 1996-03-17
Abstract
Abstract An untriakontapeptide having significant opiate agonist activity has been isolated from camel pituitary glands. The structure of this peptide has been determined and this peptide was then synthesized utilizing solid phase peptide synthesis. Both natural and synthetic material show identical physical and biological properties.
Inventors
- 👤 Choh Hao Li
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 18:06
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; C07K14/675; A; A61; A61P; A61P25/00; A61P25/04; A61P5/00; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/28
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
23 words
A compound of the formula Boc-Tyr(oBr-Z)-Gly-Gly-Phe-Met-Thr-Ser(Bzl)-Glu(OBzl)-Lys(oBr-Z)-Ser(Bzl)-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys(oBr-Z)-Asn-Ala-Ile-Ile-Lys(oBr-Z)-Asn-Ala-His(Boc)-Lys(oBr-Z)-Lys(oBr-Z)-Gly-Gln-R wherein oBr-Z is ortho bromobenzyloxycarbonyl; Bzl is benzyl; Boc is toxycarbonyl and R is styrene-divinylbenzene copolymer resin.
Claim 2
Dependent Claim
23 words
A compound of the formula Boc-Tyr(oBr-Z)-Gly-Gly-Phe-Met-Thr-Ser(Bzl)-Glu(OBzl)-Lys(oBr-Z)-Ser(Bzl)-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys(oBr-Z)-Asn-Ala-Ile-Ile-Lys(oBr-Z)-Asn-Ala-His(Boc)-Lys(oBr-Z)-Lys(oBr-Z)-Gly-Gln-R wherein oBr-Z is ortho bromobenzyloxycarbonyl; Bzl is benzyl; Boc is toxycarbonyl and R is styrene-divinylbenzene copolymer resin.
Claim 3
Dependent Claim
32 words
A compound of the formula H-tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-X-Lys-Asn-Ala-Y-Lys-Lys-Gly-Z-OH wherein X is Ile or Val; Y is His or Tyr and Z is Gln or Glu said compound being essentially free of other biogenic peptides.
Claim 4
Dependent Claim
32 words
A compound of the formula H-tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-X-Lys-Asn-Ala-Y-Lys-Lys-Gly-Z-OH wherein X is Ile or Val; Y is His or Tyr and Z is Gln or Glu said compound being essentially free of other biogenic peptides.
Claim 5
Dependent Claim
16 words
The compound of claim 4 wherein X is Ile; Y is His and Z is Gln.
Claim 6
Dependent Claim
16 words
The compound of claim 2 wherein X is Val; Y is His and Z is Gln.
Claim 7
Dependent Claim
16 words
The compound of claim 2 wherein X is Ile; Y is Tyr and Z is Glu.
Claim 8
Dependent Claim
22 words
A compound of the formula Boc-Tyr(oBr-Z)-Gly-Gly-Phe-Met-Thr-Ser(Bzl)-Glu(OBzl)-Lys-(oBr-Z)-Ser(Bzl)-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys(oBr-Z)-Asn-Ala-Ile-Val-Lys-(oBr-Z)-Asn-Ala-His(Boc)-Lys(oBr-Z)-Lys(oBr-Z)-Gly-Gln-R wherein OBr-Z is orthobromobenzyloxycarbonyl; Bzl is benzyl; Boc is t-butyloxycarbonyl and R is styrene-divinylbenzene copolymer resin.
Claim 9
Dependent Claim
22 words
A compound of the formula Boc-Tyr(oBr-Z)-Gly-Gly-Phe-Met-Thr-Ser(Bzl)-Glu(OBzl)-Lys-(oBr-Z)-Ser(Bzl)-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys(oBr-Z)-Asn-Ala-Ile-Val-Lys-(oBr-Z)-Asn-Ala-His(Boc)-Lys(oBr-Z)-Lys(oBr-Z)-Gly-Gln-R wherein OBr-Z is orthobromobenzyloxycarbonyl; Bzl is benzyl; Boc is t-butyloxycarbonyl and R is styrene-divinylbenzene copolymer resin.
Claim 10
Dependent Claim
22 words
A compound of the formula: Boc-Tyr(oBr-Z)-Gly-Gly-Phe-Met-Thr-Ser(Bzl)-Glu(OBzl)-Lys(oBr-Z)-Ser(Bzl)-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys(oBr-Z)-Asn-Ala-Ile-Ile-Lys(oBr-Z)-Asn-Ala-Tyr(oBr-Z)-Lys(oBr-Z)-Lys(oBr-Z)-Gly-Glu(Bzl)-R wherein oBr-Z is orthobromobenzyloxycarbonyl; Bzl is benzyl; Boc is t-butyloxycarbonyl and R is styrene-divinylbenzene copolymer resin.
Claim 11
Dependent Claim
22 words
A compound of the formula: Boc-Tyr(oBr-Z)-Gly-Gly-Phe-Met-Thr-Ser(Bzl)-Glu(OBzl)-Lys(oBr-Z)-Ser(Bzl)-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys(oBr-Z)-Asn-Ala-Ile-Ile-Lys(oBr-Z)-Asn-Ala-Tyr(oBr-Z)-Lys(oBr-Z)-Lys(oBr-Z)-Gly-Glu(Bzl)-R wherein oBr-Z is orthobromobenzyloxycarbonyl; Bzl is benzyl; Boc is t-butyloxycarbonyl and R is styrene-divinylbenzene copolymer resin.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-25 | 1981-01-24 | 1981-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-25 | 1985-01-24 | 1985-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-25 | 1989-01-24 | 1989-07-26 | $7700.00 | Window Closed / Lapsed |