US4037794A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Granulation apparatus
Assignee: Dierks and Soehne GmbH and Co KG
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Filing: 1974-09-23
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Granted: 1977-07-26
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Expires: 1994-09-23
Abstract
Abstract This invention provides an apparatus for the preparation of dry-medicament granulation. The apparatus comprises an enclosed-circular mixing chamber containing mixing means with a separate air inlet means and air outlet means, both of which are in flow communication with the chamber. The air outlet means is provided with a collecting bag for collecting the dry-fine particles of the medicament granulation and is equipped with a vibrator for returning them to the mixing chamber. The apparatus provides a means for a one step preparation in a batch process of medicament granulations, whereby the granulations may be directly compressed into solid-dosage forms without further processing.
Inventors
- 👤 Guido W. Melliger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 16:15
CPC Classifications
A; A61; A61J; A61J3/00; B; B01; B01J; B01J2/00; B01J2/10
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
98 words
In an apparatus for the preparation of dry medicament granulations, an enclosed circular mixing chamber which is axially symmetrical about a vertical axis, sealable first means in communication with the chamber for introducing ungranulated medicament directly into the chamber, second means in communication with the chamber and disposed in spaced relation to the first sealable means for introducing granulating liquids into the chamber, rotatable mixing means supported within the chamber, third means in communication with the chamber for introducing drying air into the chamber, and fourth means in communication with the chamber for withdrawing air from the chamber.
Claim 2
Dependent Claim
98 words
In an apparatus for the preparation of dry medicament granulations, an enclosed circular mixing chamber which is axially symmetrical about a vertical axis, sealable first means in communication with the chamber for introducing ungranulated medicament directly into the chamber, second means in communication with the chamber and disposed in spaced relation to the first sealable means for introducing granulating liquids into the chamber, rotatable mixing means supported within the chamber, third means in communication with the chamber for introducing drying air into the chamber, and fourth means in communication with the chamber for withdrawing air from the chamber.
Claim 3
Dependent Claim
21 words
Apparatus as defined in claim 1, in which the air withdrawing means comprises means for collecting fine granular particles of medicament.
Claim 4
Dependent Claim
44 words
Apparatus as defined in claim 1, in which the mixing means comprises, in combination, a plurality of mixing blades rotatable about the vertical axis, and a plurality of chopper blades disposed in spaced relation to the mixing blades and rotatable about a horizontal axis.
Claim 5
Dependent Claim
22 words
Apparatus as defined in claim 2, in which the collecting means comprises filter means impervious to the fine granular particles of medicament.
Claim 6
Dependent Claim
27 words
Apparatus as defined in claim 4, in which the collecting means further comprises vibrating means copperable with the filter means and operable to agitate the filter means.
Claim 7
Dependent Claim
22 words
Apparatus as defined in claim 1, in which the drying air introducing means are disposed on the top of the mixing chamber.
Claim 8
Dependent Claim
16 words
Apparatus as defined in claim 3, further comprising first variable-velocity means for driving the mixing blades.
Claim 9
Dependent Claim
16 words
Apparatus as defined in claim 3, further comprising second variable-velocity means for driving the chopper blades.
Claim 10
Dependent Claim
30 words
Apparatus as defined in claim 1, further comprising heating means associated with the drying air introducing means for raising the temperature of the introduced drying air to a selectable value.
Claim 11
Dependent Claim
117 words
In an apparatus for the preparation of dry medicament granulations, an enclosed circular mixing chamber axially symmetrical about a vertical axis, first sealable means in communication with the chamber for introducing ungranulated medicament directly into the chamber, second means in communication with the chamber and disposed in spaced relation to the first sealable means for introducing granulating liquid into the chamber, rotatable mixing means supported within the chamber, third means communicating with the chamber for introducing drying air into the chamber tangentially to the chamber walls, the mixing means effecting a vortex-like flow of the medicament and the granulating liquid in the chamber, and fourth means in communication with the chamber for withdrawing air from the chamber.
Claim 12
Dependent Claim
117 words
In an apparatus for the preparation of dry medicament granulations, an enclosed circular mixing chamber axially symmetrical about a vertical axis, first sealable means in communication with the chamber for introducing ungranulated medicament directly into the chamber, second means in communication with the chamber and disposed in spaced relation to the first sealable means for introducing granulating liquid into the chamber, rotatable mixing means supported within the chamber, third means communicating with the chamber for introducing drying air into the chamber tangentially to the chamber walls, the mixing means effecting a vortex-like flow of the medicament and the granulating liquid in the chamber, and fourth means in communication with the chamber for withdrawing air from the chamber.
Claim 13
Dependent Claim
34 words
The improvement in an apparatus for the preparation of dry medicament granulations as set forth in claim 10, wherein said air-introducing means cooperates with said mixing means to effect said vortex-like flow of medicament.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-25 | 1981-01-24 | 1981-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-25 | 1985-01-24 | 1985-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-25 | 1989-01-24 | 1989-07-26 | $7700.00 | Window Closed / Lapsed |