US4036983A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ferrocene compounds and pharmaceutical composition for use in treatment of iron deficiency in an animal
Assignee: Fisons Ltd
•
Filing: 1976-01-07
•
Granted: 1977-07-19
•
Expires: 1996-01-07
Abstract
Abstract These are described compounds of formula I, ##STR1## in which R is a cycloalkyl group, N IS 0, 1 OR 2, R' is hydrogen, phenyl, alkyl C 1 to 6, cycloalkyl C 4 to 6, alkyl-cycloalkyl C 5 to 8, or phenyl-(alkyl C 1 to 6), x is a whole number from 0 to 8, and y is a whole number from 0 to 5. There are also described processes for making the compounds and pharmaceutical, e.g. haematinic, compositions containing the compounds.
Inventors
- 👤 David Rutherford
- 👤 Peter Williams
- 👤 Richard Anthony Raphael
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 03:33
CPC Classifications
C; C07; C07F; C07F17/00; C07F17/02
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
63 words
A compound of formula I, ##STR5## in which R is a cycloalkyl group, n is 0, 1 or 2, R' is hydrogen, phenyl, alkyl C 1 to 6, cycloalkyl C 4 to 6, alkyl-cycloalkyl C 5 to 8, or phenyl-(alkyl C 1 to 6), x is a whole number from 0 to 8, and y is a whole number from 0 to 5.
Claim 2
Dependent Claim
63 words
A compound of formula I, ##STR5## in which R is a cycloalkyl group, n is 0, 1 or 2, R' is hydrogen, phenyl, alkyl C 1 to 6, cycloalkyl C 4 to 6, alkyl-cycloalkyl C 5 to 8, or phenyl-(alkyl C 1 to 6), x is a whole number from 0 to 8, and y is a whole number from 0 to 5.
Claim 3
Dependent Claim
39 words
A compound according to claim 1, wherein R, n, x and y are as defined in claim 1, and R' is hydrogen, phenyl, alkyl C 1 to 6, cycloalkyl C 4 to 6 or alkyl-cycloalkyl C 5 to 8.
Claim 4
Dependent Claim
12 words
A compound according to claim 1, wherein R is cyclopentyl or cyclohexyl.
Claim 5
Dependent Claim
16 words
A compound according to claim 1, wherein R' is hydrogen, ethyl, cyclohexyl, phenyl, benzyl or cyclohexylmethyl.
Claim 6
Dependent Claim
10 words
A compound according to claim 4, wherein R' is hydrogen.
Claim 7
Dependent Claim
14 words
A compound according to claim 1, wherein x is 0, 1, 2 or 3.
Claim 8
Dependent Claim
12 words
A compound according to claim 6, wherein n is 0 or 1.
Claim 9
Dependent Claim
10 words
A compound according to claim 7, wherein y is 0.
Claim 10
Dependent Claim
10 words
A compound according to claim 1, which is 3-(Cyclohexylthio)propionyl ferrocene.
Claim 11
Dependent Claim
19 words
A compound according to claim 1 and selected from 2-(cyclohexylthio)butyrylferrocene, cyclohexylsulphinylpropionylferrocene, cyclohexylthioacetylferrocene, cyclopentylthioacetylferrocene, 3-(cyclobutylthio)propionylferrocene, 3-(cycloheptylthio)propionylferrocene, 3-(cyclohexylmethylthio)propionylferrocene, 3-(cyclohexylthio)butyrylferrocene, and 2-(cyclohexylthio)phenylpropionylferrocene.
Claim 12
Dependent Claim
21 words
A compound according to claim 1 in a solid particulate form having a mass median diameter of less than 10 microns.
Claim 13
Dependent Claim
38 words
A pharmaceutical composition for use in treatment of iron deficiency in an animal comprising a therapeutically effective amount of a compound according to claim 1, as active ingredient, in combination with a pharmaceutically acceptable adjuvant, diluent or carrier.
Claim 14
Dependent Claim
19 words
A composition according to claim 12, comprising from 20 to 2,000 mg of active ingredient in unit dosage form.
Claim 15
Dependent Claim
29 words
A method of treating iron deficiency in an animal, which comprises administering an effective quantity of a compound according to claim 1 to an animal suffering from iron deficiency.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-18 | 1981-01-17 | 1981-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-18 | 1985-01-17 | 1985-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-18 | 1989-01-17 | 1989-07-19 | $7700.00 | Window Closed / Lapsed |