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US4036972A
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2-(N-thienylmethyl-phenylamino)-imidazolines-(2) and salts thereof
Assignee: Boehringer Ingelheim GmbH
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Filing: 1975-08-25
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Granted: 1977-07-19
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Expires: 1995-08-25
Abstract
Abstract Compounds of the formula ##STR1## wherein R, R 1 and R 2 are each hydrogen, fluorine, chlorine, bromine, methoxy or trifluoromethyl, but other than all hydrogen at the same time, and R 3 is hydrogen, methyl or ethyl, And non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and hypotensives.
Inventors
- 👤 Helmut Stahle
- 👤 Herbert Koppe
- 👤 Werner Kummer
- 👤 Klaus Stockhaus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:49
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; G; G03; G03G; G03G15/00; G03G15/06; G03G15/08
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
46 words
a compound of the formula ##STR7## wherein R, R 1 and R 2 are each hydrogen, fluorine, chlorine or bromine, but other than all hydrogen at the same time, and R 3 is hydrogen, methyl or ethyl, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
46 words
a compound of the formula ##STR7## wherein R, R 1 and R 2 are each hydrogen, fluorine, chlorine or bromine, but other than all hydrogen at the same time, and R 3 is hydrogen, methyl or ethyl, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
17 words
A compound of claim 1, which is 2-[N-(thienyl-(2)-methyl)-N-(2,6-dichloro-4-bromophenyl)-amino]-2-imidazoline or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
17 words
A compound of claim 1, which is 2-[N-(3-methyl-thienyl-(2)-methyl)-N-(2,6-dichlorophenyl)-amino]-2-imidazoline or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
17 words
A compound of claim 1, which is 2-[N-(thienyl-(2)-methyl)-N-(2,4-difluoro-phenyl)-amino]-2-imidazoline or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
37 words
A compound of the formula ##STR8## wherein R 1 and R 2 are each hydrogen, fluorine, chlorine or bromine, but other than all hydrogen at the same time, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
37 words
A compound of the formula ##STR8## wherein R 1 and R 2 are each hydrogen, fluorine, chlorine or bromine, but other than all hydrogen at the same time, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
17 words
A compound of claim 5, which is 2-[N-(thienyl-(2)-methyl)-N-(2,6-dichloro-phenyl)-amino]-2-imidazoline or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 9
Dependent Claim
17 words
A compound of claim 5, which is 2-[N-(thienyl-(3)-methyl)-N-(2,6-dichloro-phenyl)-amino]-2-imidazoline or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
19 words
Analgesic compositions comprising an inert pharmaceutical carrier and an effective amount of at least one compound of claim 1.
Claim 11
Dependent Claim
26 words
A method of relieving pain in warm-blooded animals, which comprises administering to warm-blooded animals an analgesically effective amount of at least one compound of claim 1.
Claim 12
Dependent Claim
19 words
Analgesic compositions comprising an inert pharmaceutical carrier and an effective amount of at least one compound of claim 5.
Claim 13
Dependent Claim
26 words
A method of relieving pain in warm-blooded animals, which comprises administering to warm-blooded animals an analgesically effective amount of at least one compound of claim 5.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-18 | 1981-01-17 | 1981-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-18 | 1985-01-17 | 1985-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-18 | 1989-01-17 | 1989-07-19 | $7700.00 | Window Closed / Lapsed |