US4036957A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenoxy compounds in combinations to suppress gastric bleeding in aspirin therapy
Assignee: AH Robins Co Inc
•
Filing: 1975-11-18
•
Granted: 1977-07-19
•
Expires: 1995-11-18
Abstract
Abstract Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenoxy- and substituted-phenoxy alcohols, carbamates, aminoalcohols, carbamoylalcohols, oxazolidinones, pyrrolidines, thiosemicarbazides and aminoalkylacetamides. The compounds act systemically to ameliorate gastric bleeding otherwise caused by aspirin.
Inventors
- 👤 Reevis Stancil Alphin
- 👤 John Wesley Ward
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 06:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
87 words
The method of treating inflammatory conditions in mammals which comprises administering to said mammals an effective amount of a combination of from about 67 to 95% by weight aspirin and from about 5 to 33% by weight of a phenoxy compound having the formula: ##STR7## wherein; R is selected from the group consisting of hydrogen, chlorine, bromine, fluorine, lower-alkyl, lower-alkoxy, or trifluoromethyl, R 1 is selected from the group consisting of hydrogen, chlorine, bromine, fluorine, lower-alkyl or lower-alkoxy, and R 2 is --CH 2 --CHCH 2 NHCOO.
Claim 2
Independent Claim
87 words
The method of treating inflammatory conditions in mammals which comprises administering to said mammals an effective amount of a combination of from about 67 to 95% by weight aspirin and from about 5 to 33% by weight of a phenoxy compound having the formula: ##STR7## wherein; R is selected from the group consisting of hydrogen, chlorine, bromine, fluorine, lower-alkyl, lower-alkoxy, or trifluoromethyl, R 1 is selected from the group consisting of hydrogen, chlorine, bromine, fluorine, lower-alkyl or lower-alkoxy, and R 2 is --CH 2 --CHCH 2 NHCOO.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the phenoxy compound is 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the phenoxy compound is 5-(2,4-dichlorphenoxymethyl)-2-oxazolidinone.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-18 | 1981-01-17 | 1981-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-18 | 1985-01-17 | 1985-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-18 | 1989-01-17 | 1989-07-19 | $7700.00 | Window Closed / Lapsed |