US4036864A
Expired / Lapsed
US
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Chemical process
Assignee: Research Institute for Medicine and Chemistry Inc
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Filing: 1975-05-27
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Granted: 1977-07-19
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Expires: 1995-05-27
Abstract
Abstract Saturated organic compounds containing a hydrogen atom bound to a tertiary carbon atom may be electrophilically fluorinated by reaction with an electrophilic fluorinating agent such as molecular fluorine or trifluoromethyl hypofluorite under conditions whereby the formation of free fluorine radicals is suppressed, e.g. by the presence of a free radical inhibitor such as oxygen or nitrobenzene, the reactants being substantially homogeneously dispersed in a liquid medium, e.g. a solvent medium such as fluorotrichloromethane or chloroform/fluorotrichloromethane, so that the said hydrogen atom is electrophilically replaced by a fluorine atom. The fluoroination is highly selective and, in the case of complex substrates such as saturated steroids which contain a number of tertiary C--H bonds, may be substantially completely confined to replacement of the hydrogen atom at the tertiary carbon atom which has the highest electron density about the C--H bond. The electron density and thus the direction of the fluorination may be controlled by appropriate selection of substituent groupings in the substrate molecule. Novel 14α-fluorosteroids are also disclosed, including compounds having valuable androgenic or progestational activity and useful synthetic intermediates.
Inventors
- 👤 Derek Harold Richard Barton
- 👤 Robert Henry Hesse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:25
CPC Classifications
C; C07; C07J; C07J53/00; C07B; C07B39/00; C07C; C07C17/00; C07C17/093; C07C17/10; C07J1/00; C07J1/0003; C07J1/0011; C07J1/0018; C07J1/0022; C07J1/0025; C07J41/00; C07J41/0033; C07J41/005; C07J5/00; C07J5/0046; C07J5/0061; C07J5/0069; C07J5/0076; C07J7/00; C07J7/0005; C07J7/001; C07J7/0015; C07J7/002; C07J7/004; C07J7/005; C07J7/0055; C07J9/00
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
217 words
A process for the 9α-electrophilic fluorination of a saturated steroid compound containing a hydrogen atom bound to a tertiary carbon atom, wherein said steroid has a formula: ##STR10## where R 4 represents protected hydroxy and R 5 represents hydrogen, or R 4 and R 5 together represent a keto or protected keto group, and R 6 and R 7 each represent hydrogen, or R 4 and R 6 together represent a 3,5-cyclo linkage, R 5 represents hydrogen and R 7 represents protected hydroxy; R 8 represents hydrogen, methyl or protected hydroxy; R 9 represents hydrogen, hydroxy or protected hydroxy and R 10 represents acetyl or substituted acetyl, or R 9 represents hydrogen and R 10 represents protected hydroxy, or R 9 and R 10 together represent a keto group; which comprises reacting the said steriod with an electrophilic fluorinating agent selected from the group consisting of molecular fluorine, pentafluorosulphur hypofluorite and lower fluoroalkyl hypofluorites in which the fluoroalkyl moiety contains at least two fluorine atoms per carbon atom, said fluorinating agent being substantially homogeneously dispersed in a liquid medium and said reaction being conducted in the presence of a free radical inhibitor to suppress formation of free fluorine radicals so that said hydrogen atom is electrophilically replaced by a fluorine atom, and recovering the thus-obtained fluoro steroid.
Claim 2
Dependent Claim
217 words
A process for the 9α-electrophilic fluorination of a saturated steroid compound containing a hydrogen atom bound to a tertiary carbon atom, wherein said steroid has a formula: ##STR10## where R 4 represents protected hydroxy and R 5 represents hydrogen, or R 4 and R 5 together represent a keto or protected keto group, and R 6 and R 7 each represent hydrogen, or R 4 and R 6 together represent a 3,5-cyclo linkage, R 5 represents hydrogen and R 7 represents protected hydroxy; R 8 represents hydrogen, methyl or protected hydroxy; R 9 represents hydrogen, hydroxy or protected hydroxy and R 10 represents acetyl or substituted acetyl, or R 9 represents hydrogen and R 10 represents protected hydroxy, or R 9 and R 10 together represent a keto group; which comprises reacting the said steriod with an electrophilic fluorinating agent selected from the group consisting of molecular fluorine, pentafluorosulphur hypofluorite and lower fluoroalkyl hypofluorites in which the fluoroalkyl moiety contains at least two fluorine atoms per carbon atom, said fluorinating agent being substantially homogeneously dispersed in a liquid medium and said reaction being conducted in the presence of a free radical inhibitor to suppress formation of free fluorine radicals so that said hydrogen atom is electrophilically replaced by a fluorine atom, and recovering the thus-obtained fluoro steroid.
Claim 3
Dependent Claim
27 words
A process as claimed in claim 1 wherein the electrophilic fluorinating agent is selected from the group consisting of molecular fluorine diluted with nitrogen and trifluoromethyl hypofluorite.
Claim 4
Dependent Claim
24 words
A process as claimed in claim 1 wherein the free radical inhibitor is selected from the group consisting of oxygen, nitrobenzene, m-dinitrobenzene and benzoquinone.
Claim 5
Dependent Claim
31 words
A process as claimed in claim 1 wherein chloroform, methylene chloride or tetrahydrofuran is employed as a free radical inhibitor and the electrophilic fluorinating agent is molecular fluorine diluted with nitrogen.
Claim 6
Dependent Claim
25 words
A process as claimed in claim 1 wherein the fluorination is carried out in the presence of a substance which binds or adsorbs hydrogen fluoride.
Claim 7
Dependent Claim
28 words
A process as claimed in claim 1 wherein, after the fluorination, a base is added to the crude fluoro steroid product in order to stabilize the said product.
Claim 8
Dependent Claim
91 words
A process as claimed in claim 1 wherein R 4 represents acetoxy, trifluoroacetoxy or nitrooxy and R 5 represents hydrogen, or R 4 and R 5 together represent a keto group, and R 6 and R 7 each represent hydrogen, or R 4 and R 6 form a 3,5-cyclo linkage, R 5 represents hydrogen and R 7 represents acetoxy; R 8 represents hydrogen or methyl; R 9 represents hydrogen, hydroxy or nitrooxy and R 10 represents acetyl or acetoxyacetyl, or R 9 represents hydrogen and R 10 represents acetoxy or trifluoroacetoxy.
Claim 9
Dependent Claim
211 words
A process for the 14α-electrophilic fluorination of a saturated steroid compound containing a hydrogen atom bound to a tertiary carbon atom, wherein said steroid has a formula: ##STR11## where R 11 represents protected hydroxy and R 12 represents hydrogen, or R 11 and R 12 together represent a keto or protected keto group, R 13 represents hydrogen and R 14 and R 15 each represent halogen, or R 14 together with R 13 or R 15 represents an epoxy group, the remaining R 13 or R 15 representing hydrogen, or R 11 and R 14 together represent a 3,5-cyclo linkage, R 12 and R 13 each represent hydrogen and R 15 represents protected hydroxy; and R 16 represents oxo, acetyl or protected hydroxy; which comprises reacting the said steroid with an electrophilic fluorinating agent selected from the group consisting of molecular fluorine, pentafluorosulphur hypofluorite and lower fluoroalkyl hypofluorites in which the fluoroalkyl moiety contains at least two fluorine atoms per carbon atom, said fluorinating agent being substantially homogeneously dispersed in a liquid medium and said reaction being conducted in the presence of a free radical inhibitor to suppress formation of free fluorine radicals so that said hydrogen atom is electrophilically replaced by a fluorine atom, and recovering the thus-obtained fluoro steroid.
Claim 10
Dependent Claim
211 words
A process for the 14α-electrophilic fluorination of a saturated steroid compound containing a hydrogen atom bound to a tertiary carbon atom, wherein said steroid has a formula: ##STR11## where R 11 represents protected hydroxy and R 12 represents hydrogen, or R 11 and R 12 together represent a keto or protected keto group, R 13 represents hydrogen and R 14 and R 15 each represent halogen, or R 14 together with R 13 or R 15 represents an epoxy group, the remaining R 13 or R 15 representing hydrogen, or R 11 and R 14 together represent a 3,5-cyclo linkage, R 12 and R 13 each represent hydrogen and R 15 represents protected hydroxy; and R 16 represents oxo, acetyl or protected hydroxy; which comprises reacting the said steroid with an electrophilic fluorinating agent selected from the group consisting of molecular fluorine, pentafluorosulphur hypofluorite and lower fluoroalkyl hypofluorites in which the fluoroalkyl moiety contains at least two fluorine atoms per carbon atom, said fluorinating agent being substantially homogeneously dispersed in a liquid medium and said reaction being conducted in the presence of a free radical inhibitor to suppress formation of free fluorine radicals so that said hydrogen atom is electrophilically replaced by a fluorine atom, and recovering the thus-obtained fluoro steroid.
Claim 11
Dependent Claim
27 words
A process as claimed in claim 8 wherein the electrophilic fluorinating agent is selected from the group consisting of molecular fluorine diluted with nitrogen and trifluoromethyl hypofluorite.
Claim 12
Dependent Claim
24 words
A process as claimed in claim 8 wherein the free radical inhibitor is selected from the group consisting of oxygen, nitrobenzene, m-dinitrobenzene and benzoquinone.
Claim 13
Dependent Claim
31 words
A process as claimed in claim 8 wherein chloroform, methylene chloride or tetrahydrofuran is employed as a free radical inhibitor and the electrophilic fluorinating agent is molecular fluorine diluted with nitrogen.
Claim 14
Dependent Claim
25 words
A process as claimed in claim 8 wherein the fluorination is carried out in the presence of a substance which binds or adsorbs hydrogen fluoride.
Claim 15
Dependent Claim
28 words
A process as claimed in claim 8 wherein, after the fluorination, a base is added to the crude fluoro steroid product in order to stabilize the said product.
Claim 16
Dependent Claim
77 words
A process as claimed in claim 8 wherein R 11 represents acetoxy, trifluoroacetoxy or nitrooxy and R 12 represents hydrogen, or R 11 and R 12 together represent a keto group, R 13 represents hydrogen and R 14 and R 15 each represent chloro or bromo, or R 11 and R 14 form a 3,5-cyclo linkage, R 12 and R 13 each represent hydrogen and R 15 represents acetoxy; and R 16 represents oxo, acetyl or acetoxy.
Claim 17
Dependent Claim
212 words
A process for the 17α-electrophilic fluorination of a saturated steroid compound containing a hydrogen atom bound to a tertiary carbon atom, wherein said steriod has a formula: ##STR12## wherein R 11 represents protected hydroxy and R 12 represents hydrogen, or R 11 and R 12 together represent a keto or protected keto group, R 13 represents hydrogen and R 14 and R 15 each represent halogen, or R 14 together with R 13 or R 15 represents an epoxy group, the remaining R 13 or R 15 representing hydrogen, or R 11 and R 14 together represent a 3,5-cyclo linkage, R 12 and R 13 each represent hydrogen and R 15 represents protected hydroxy; and R 17 represents a C 2-12 saturated hydrocarbyl group which comprises reacting the said steriod with an electrophilic fluorinating agent selected from the group consisting of molecular fluorine, pentafluorosulphur hypofluorite and lower fluoroalkyl hypofluorites in which the fluoroalkyl moiety contains at least two fluorine atoms per carbon atom, said fluorinating agent being substantially homogeneously dispersed in a liquid medium and said reaction being conducted in the presence of a free radical inhibitor to suppress formation of free fluorine radicals so that said hydrogen atom is electrophilically replaced by a fluorine atom, and recovering the thus-obtained fluoro steroid.
Claim 18
Dependent Claim
212 words
A process for the 17α-electrophilic fluorination of a saturated steroid compound containing a hydrogen atom bound to a tertiary carbon atom, wherein said steriod has a formula: ##STR12## wherein R 11 represents protected hydroxy and R 12 represents hydrogen, or R 11 and R 12 together represent a keto or protected keto group, R 13 represents hydrogen and R 14 and R 15 each represent halogen, or R 14 together with R 13 or R 15 represents an epoxy group, the remaining R 13 or R 15 representing hydrogen, or R 11 and R 14 together represent a 3,5-cyclo linkage, R 12 and R 13 each represent hydrogen and R 15 represents protected hydroxy; and R 17 represents a C 2-12 saturated hydrocarbyl group which comprises reacting the said steriod with an electrophilic fluorinating agent selected from the group consisting of molecular fluorine, pentafluorosulphur hypofluorite and lower fluoroalkyl hypofluorites in which the fluoroalkyl moiety contains at least two fluorine atoms per carbon atom, said fluorinating agent being substantially homogeneously dispersed in a liquid medium and said reaction being conducted in the presence of a free radical inhibitor to suppress formation of free fluorine radicals so that said hydrogen atom is electrophilically replaced by a fluorine atom, and recovering the thus-obtained fluoro steroid.
Claim 19
Dependent Claim
27 words
A process as claimed in claim 15 wherein the electrophilic fluorinating agent is selected from the group consisting of molecular fluorine diluted with nitrogen and trifluoromethyl hypofluorite.
Claim 20
Dependent Claim
24 words
A process as claimed in claim 15 wherein the free radical inhibitor is selected from the group consisting of oxygen, nitrobenzene, m-dinitrobenzene and benzoquinone.
Claim 21
Dependent Claim
31 words
A process as claimed in claim 15 wherein chloroform, methylene chloride or tetrahydrofuran is employed as a free radical inhibitor and the electrophilic fluorinating agent is molecular fluorine diluted with nitrogen.
Claim 22
Dependent Claim
25 words
A process as claimed in claim 15 wherein the fluorination is carried out in the presence of a substance which binds or adsorbs hydrogen fluoride.
Claim 23
Dependent Claim
28 words
A process as claimed in claim 15 wherein, after the fluorination, a base is added to the crude fluoro steroid product in order to stabilize the said product.
Claim 24
Dependent Claim
57 words
A process as claimed in claim 15 wherein R 11 represents nitrooxy or trifluoroacetoxy; R 12 and R 13 each represent hydrogen; R 14 and R 15 both represent chloro or bromo or together form an epoxy group; and R 17 represents the group --CH(CH 3 ) . (CH 2 ) 3 .CH(CH 3 ) 2 .
Claim 25
Dependent Claim
143 words
A compound having the formula: ##STR13## wherein R 18 represents hydroxy, nitroxy, acetoxy or trifluoroacetoxy and R 19 represents hydrogen or R 18 and R 19 together represent a keto group, R 20 represents hydrogen and R 21 and R 22 both represent hydrogen, chlorine or bromine or together form a carbon-carbon double bond or an epoxy group, and when R 18 and R 19 together represent a keto group R 20 and R 21 may together form a carbon-carbon double bond or an epoxy group, R 22 then being hydrogen, or R 18 and R 21 together form a 3,5-cyclo linkage, R 19 and R 20 then being hydrogen and R 22 being acetoxy; R 23 represents hydrogen or methyl; R 24 represents hydrogen or hydroxy and R 25 represents acetoxy, or R 24 and R 25 together represent a keto group.
Claim 26
Dependent Claim
143 words
A compound having the formula: ##STR13## wherein R 18 represents hydroxy, nitroxy, acetoxy or trifluoroacetoxy and R 19 represents hydrogen or R 18 and R 19 together represent a keto group, R 20 represents hydrogen and R 21 and R 22 both represent hydrogen, chlorine or bromine or together form a carbon-carbon double bond or an epoxy group, and when R 18 and R 19 together represent a keto group R 20 and R 21 may together form a carbon-carbon double bond or an epoxy group, R 22 then being hydrogen, or R 18 and R 21 together form a 3,5-cyclo linkage, R 19 and R 20 then being hydrogen and R 22 being acetoxy; R 23 represents hydrogen or methyl; R 24 represents hydrogen or hydroxy and R 25 represents acetoxy, or R 24 and R 25 together represent a keto group.
Claim 27
Dependent Claim
9 words
The compound of claim 22 which is a 14α-fluoroandrost-4-ene-3,17-dione.
Claim 28
Dependent Claim
9 words
The compound of claim 22 which is a 14α-fluorotestosterone.
Claim 29
Dependent Claim
8 words
The compound of claim 22 which is 14α-fluoroprogesterone.
References Cited (Backward Citations)
US3687943A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-18 | 1981-01-17 | 1981-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-18 | 1985-01-17 | 1985-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-18 | 1989-01-17 | 1989-07-19 | $7700.00 | Window Closed / Lapsed |