US4035369A
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1-Benzazolylalkyl-4-substituted-piperidines
Assignee: Janssen Pharmaceutica NV
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Filing: 1976-08-10
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Granted: 1977-07-12
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Expires: 1996-08-10
Abstract
Abstract Compounds of the class of 1-(benzazolyalkyl)piperidine derivatives, useful as neuroleptic agents.
Inventors
- 👤 Jan Vandenberk
- 👤 Ludo E. J. Kennis
- 👤 Marcel J. M. C. Van der Aa
- 👤 Albert H. M. Th. Van Heertum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:34
CPC Classifications
C; C07; C07D; C07D235/00; C07D235/02; C07D235/04; C07D235/06; A; A61; A61P; A61P25/00; A61P25/08; A61P25/20; A61P25/24; A61P25/26; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D211/30; C07D211/32; C07D235/08; C07D235/24; C07D235/26; C07D235/28; C07D405/00; C07D405/02; C07D405/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
138 words
A chemical compound selected from the group consisting of a piperidine derivative having the formula: ##STR46## and the pharmaceutically acceptable acid addition salts thereof, wherein: R is a member selected from the group consisting of hydrogen and halo; R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; n is an integer of from 2 to 4 inclusive; Q is a member selected from the group consisting of ##STR47## and ##STR48## wherein R 3 is lower alkyl and m is an integer of from 2 to 3 inclusive; and A is a bivalent radical selected from the group consisting of ##STR49## wherein L is selected from the group consisting of hydrogen, lower alkylthio, cyclohexyl and phenylmethyl, said bivalent radical being attached to the benzene nucleus by its heteroatom.
Claim 2
Dependent Claim
138 words
A chemical compound selected from the group consisting of a piperidine derivative having the formula: ##STR46## and the pharmaceutically acceptable acid addition salts thereof, wherein: R is a member selected from the group consisting of hydrogen and halo; R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; n is an integer of from 2 to 4 inclusive; Q is a member selected from the group consisting of ##STR47## and ##STR48## wherein R 3 is lower alkyl and m is an integer of from 2 to 3 inclusive; and A is a bivalent radical selected from the group consisting of ##STR49## wherein L is selected from the group consisting of hydrogen, lower alkylthio, cyclohexyl and phenylmethyl, said bivalent radical being attached to the benzene nucleus by its heteroatom.
Claim 3
Dependent Claim
18 words
A chemical compound selected from the group consisting of 5-chloro-1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl}-1,3-dihydro2H-benzimidazol-2-one and the pharmaceutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
18 words
A chemical compound selected from the group consisting of 5-chloro-1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl}-1,3-dihydro2H-benzimidazol-2-one and the pharmaceutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl}-1,3-dihydro-5-methyl-2H-benzimidazol-2-one and the pharmaceutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl}-1,3-dihydro-5-methyl-2H-benzimidazol-2-one and the pharmaceutically acceptable acid addition salts thereof.
Claim 7
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl}-1,3-dihydro-5,6-dimethyl-2H-benzimidazol-2-one and the pharmaceutically acceptable acid addition salts thereof.
Claim 8
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl}-1,3-dihydro-5,6-dimethyl-2H-benzimidazol-2-one and the pharmaceutically acceptable acid addition salts thereof.
Claim 9
Dependent Claim
19 words
A chemical compound selected from the group consisting of 1-[3-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl (4-fluorophenyl)methanone and the pharmaceutically acceptable acid addition salts thereof.
Claim 10
Dependent Claim
19 words
A chemical compound selected from the group consisting of 1-[3-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl (4-fluorophenyl)methanone and the pharmaceutically acceptable acid addition salts thereof.
Claim 11
Dependent Claim
124 words
A chemical compound having the formula ##STR50## wherein: R is a member selected from the group consisting of hydrogen and halo; R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; n is an integer of from 2 to 4 inclusive; Q is a member selected from the group consisting of ##STR51## and ##STR52## wherein R 3 is lower alkyl and m is an integer of from 2 to 3 inclusive; and P is a member selected from the group consisting of lower alkyloxycarbonyl and a substituted ethenyl radical having the formula: ##STR53## wherein R 4 is lower alkyl and R 5 is selected from the group consisting of hydrogen, lower alkyl and phenyl.
Claim 12
Dependent Claim
124 words
A chemical compound having the formula ##STR50## wherein: R is a member selected from the group consisting of hydrogen and halo; R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; n is an integer of from 2 to 4 inclusive; Q is a member selected from the group consisting of ##STR51## and ##STR52## wherein R 3 is lower alkyl and m is an integer of from 2 to 3 inclusive; and P is a member selected from the group consisting of lower alkyloxycarbonyl and a substituted ethenyl radical having the formula: ##STR53## wherein R 4 is lower alkyl and R 5 is selected from the group consisting of hydrogen, lower alkyl and phenyl.
Claim 13
Dependent Claim
82 words
A chemical compound having the formula: ##STR54## wherein: R is a member selected from the group consisting of hydrogen and halo; R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; n is an integer of from 2 to 4 inclusive; and Q is a member selected from the group consisting of ##STR55## and ##STR56## wherein R 3 is lower alkyl and m is an integer of from 2 to 3 inclusive.
Claim 14
Dependent Claim
82 words
A chemical compound having the formula: ##STR54## wherein: R is a member selected from the group consisting of hydrogen and halo; R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; n is an integer of from 2 to 4 inclusive; and Q is a member selected from the group consisting of ##STR55## and ##STR56## wherein R 3 is lower alkyl and m is an integer of from 2 to 3 inclusive.
References Cited (Backward Citations)
FR1573739A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-11 | 1981-01-10 | 1981-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-11 | 1985-01-10 | 1985-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-11 | 1989-01-10 | 1989-07-12 | $7700.00 | Window Closed / Lapsed |