Patent US4913164A successfully refreshed from Google Patents.
← Back to Patent Explorer
US4034083A Expired / Lapsed US ⏱️ 0.0 years remaining

Compositions for inhibiting absorption of cholesterol

Assignee: Procter and Gamble Co
•
Filing: 1975-11-03
•
Granted: 1977-07-05
•
Expires: 1995-11-03
📄 Original PDF 🌐 Google Patents 🔄 Sync Now

Abstract

Abstract Polyol fatty acid polyesters having at least four fatty acid ester groups are fortified with fat-soluble vitamins and used in pharmaceutical compositions for treating and/or preventing hypercholesterolemia in animals, especially humans, and in low-calorie foods.

Inventors

  • 👤 Fred Hugh Mattson

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 22:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/23; A61K31/70; A61P; A61P3/00; A61P3/06

Claims Analysis

Total Claims: 27
Claim 1
Independent Claim 94 words
A composition of matter, comprising: a non-absorbable, non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 2
Dependent Claim 94 words
A composition of matter, comprising: a non-absorbable, non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 3
Dependent Claim 20 words
A composition according to claim 1 wherein the polyol fatty acid polyester contains no more than 2 free hydroxyl groups.
Claim 4
Dependent Claim 21 words
A composition according to claim 2 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 5
Dependent Claim 24 words
A composition according to claim 3 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 6
Dependent Claim 11 words
A composition according to claim 4 wherein the polyol is sucrose.
Claim 7
Dependent Claim 36 words
A composition according to claim 5 wherein the sucrose fatty acid polyester is a member selected from the group consisting of C 14 , C 16 and C 18 hexa-, hepta-, and octa-esters, and mixtures thereof.
Claim 8
Dependent Claim 31 words
A composition according to claim 6 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 9
Dependent Claim 53 words
A composition according to claim 1 which comprises from about 98% to about 99.999% by weight of the non-absorbable, non-digestible polyol fatty acid polyester and from about 0.001% to about 2% by weight of a vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K, and mixtures thereof.
Claim 10
Dependent Claim 122 words
A pharmaceutical composition in effective unit dosage amounts for inhibiting the absorption of cholesterol without interfering with the body's stores of fat-soluble vitamins, comprising: from about 0.1 gram to about 5 grams of a non-absorbable, non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, to prevent abnormally low levels of any of said fat-soluble vitamins in humans ingesting said composition.
Claim 11
Dependent Claim 122 words
A pharmaceutical composition in effective unit dosage amounts for inhibiting the absorption of cholesterol without interfering with the body's stores of fat-soluble vitamins, comprising: from about 0.1 gram to about 5 grams of a non-absorbable, non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, to prevent abnormally low levels of any of said fat-soluble vitamins in humans ingesting said composition.
Claim 12
Dependent Claim 20 words
A composition according to claim 9 wherein the polyol fatty acid polyester contains no more than 2 free hydroxyl groups.
Claim 13
Dependent Claim 21 words
A composition according to claim 10 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 14
Dependent Claim 24 words
A composition according to claim 11 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 15
Dependent Claim 11 words
A composition according to claim 12 wherein the polyol is sucrose.
Claim 16
Dependent Claim 36 words
A composition according to claim 13 wherein the sucrose fatty acid polyester is a member selected from the group consisting of C 14 , C 16 and C 18 hexa-, hepta-, and octa-esters, and mixtures thereof.
Claim 17
Dependent Claim 31 words
A composition according to claim 14 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 18
Dependent Claim 129 words
A low calorie fat-containing food composition comprising non-fat ingredients and fat ingredients wherein from about 10% to about 100% of the total fat ingredients comprise a non-absorbable, non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms, said food composition being fortified with sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, over and above that naturally present in said food composition, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 19
Dependent Claim 129 words
A low calorie fat-containing food composition comprising non-fat ingredients and fat ingredients wherein from about 10% to about 100% of the total fat ingredients comprise a non-absorbable, non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms, said food composition being fortified with sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, over and above that naturally present in said food composition, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 20
Dependent Claim 20 words
A composition according to claim 16 wherein the polyol fatty acid polyester contains no more than 2 free hydroxyl groups.
Claim 21
Dependent Claim 21 words
A composition according to claim 17 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 22
Dependent Claim 24 words
A composition according to claim 18 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 23
Dependent Claim 11 words
A composition according to claim 19 wherein the polyol is sucrose.
Claim 24
Dependent Claim 36 words
A composition according to claim 20 wherein the sucrose fatty acid polyester is a member selected from the group consisting of C 14 , C 16 and C 18 hexa-, hepta-, and octa-esters, and mixtures thereof.
Claim 25
Dependent Claim 31 words
A composition according to claim 21 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 26
Independent Claim 102 words
A method for inhibiting the absorption of cholesterol without decreasing the body's stores of fat-soluble vitamins comprising systemically administering to an animal susceptible to or afflicted with hypercholesterolemia successive therapeutically effective doses of a non-absorbable and non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms and sufficient fat-soluble vitamin to prevent abnormally low levels of said vitamin from developing in said animal.
Claim 27
Independent Claim 102 words
A method for inhibiting the absorption of cholesterol without decreasing the body's stores of fat-soluble vitamins comprising systemically administering to an animal susceptible to or afflicted with hypercholesterolemia successive therapeutically effective doses of a non-absorbable and non-digestible polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms and sufficient fat-soluble vitamin to prevent abnormally low levels of said vitamin from developing in said animal.

References Cited (Backward Citations)

US3351531A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-07-04 1981-01-03 1981-07-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-07-04 1985-01-03 1985-07-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-07-04 1989-01-03 1989-07-05 $7700.00 Window Closed / Lapsed

Assigned Categories & Tags

No categories assigned to this patent yet.

Assign Category Tag