Patent US4551146A successfully refreshed from Google Patents.
US4034073A
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Composite for biased solid phase radioimmunoassay of triiodothyronine and thyroxine
Assignee: Corning Glass Works
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Filing: 1975-03-28
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Granted: 1977-07-05
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Expires: 1995-03-28
Abstract
Abstract Immunochemical composites consisting of saturating amounts of radio-labelled triiodothyronine (T 3 ) or thyroxine (T 4 ) complexed respectively to anti-T 3 or anti-T 4 antisera covalently coupled to suspendable porous glass particles via an intermediate silane coupling agent. The composites are pre-loaded into individual tubes used in solid phase radioimmunoassay of T 3 or T 4 , requiring the addition of only test serum or standard, thereby minimizing chances of erroneous assay.
Inventors
- 👤 Howard H. Weetall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 02:17
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
49 words
A reagent useful for a solid phase radioimmunoassay of triiodothyronine comprising an aqueous suspension of an immunochemical composite consisting of a saturating amount of radioactively labelled triiodothyronine complexed to a sub-composite consisting of anti-triiodothyronine antibodies covalently coupled via an intermediate silane coupling agent to suspenable particles of porous glass.
Claim 2
Dependent Claim
49 words
A reagent useful for a solid phase radioimmunoassay of triiodothyronine comprising an aqueous suspension of an immunochemical composite consisting of a saturating amount of radioactively labelled triiodothyronine complexed to a sub-composite consisting of anti-triiodothyronine antibodies covalently coupled via an intermediate silane coupling agent to suspenable particles of porous glass.
Claim 3
Dependent Claim
44 words
The reagent of claim 1 wherein the porous glass particles of the suspension have an average pore diameter ranging from 300A to 1000A and an average particle size ranging from 0.7 μ to 4 μ and the triiodothyronine is labelled with I 125 .
Claim 4
Dependent Claim
49 words
A reagent useful for a solid phase radioimmunoassay of thyroxine comprising an aqueous suspension of an immunochemical composite consisting of a saturating amount of radioactively labelled thyroxine complexed to a sub-composite consisting of anti-thyroxine antibodies covalently coupled via an intermediate silane coupling agent to suspendable particles of porous glass.
Claim 5
Dependent Claim
49 words
A reagent useful for a solid phase radioimmunoassay of thyroxine comprising an aqueous suspension of an immunochemical composite consisting of a saturating amount of radioactively labelled thyroxine complexed to a sub-composite consisting of anti-thyroxine antibodies covalently coupled via an intermediate silane coupling agent to suspendable particles of porous glass.
Claim 6
Dependent Claim
44 words
The reagent of claim 3 wherein the porous glass particles of the suspension have an average pore diameter ranging from 300A to 1000A and an average particle size ranging from 0.7 μ to 4 μ and the thyroxine is labelled with I 125 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-04 | 1981-01-03 | 1981-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-04 | 1985-01-03 | 1985-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-04 | 1989-01-03 | 1989-07-05 | $7700.00 | Window Closed / Lapsed |