Cyclohexane tetrols and derivatives thereof

Abstract

Abstract The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## WHEREIN (CH 2 ) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R 5 .sup.° is hydrogen, alkyl, arylalkyl, and R 5 and R 6 together with the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino; R 1 , r 2 , r 3 and R 4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR3## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR4## wherein R 5 and R 6 are as previously defined and p is 0--3; 2--, 3--, or 4--pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; R 9 may be H, or a straight or branched chain alkyl radical of 1-6 carbon atoms; R 7 and R 8 may be the same or different and may be hydrogen or alkyl, and R 7 and R 8 taken together with the carbon atoms bearing substituents OR 2 and OR 4 may form a cycloalkyl ring. These compounds have been found useful in the treatment of hypertension in mammalian species, as surface active agents, as in vivo antibacterial compounds and as water softeners.

Inventors

• 👤 Frederic Peter Hauck
• 👤 Joseph E. Sundeen

Bibliographic Details