US4033824A
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Process for the determination of plasminogen
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1975-07-24
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Granted: 1977-07-05
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Expires: 1995-07-24
Abstract
Abstract The invention relates to a process for the analytical determination of human plasminogen which comprises mixing a liquid containing diluted human plasminogen with A. A CATALYST, SUCH AS STREPTOKINASE, CONVERTING HUMAN PLASMINOGEN INTO HUMAN PLASMINOGEN ACTIVATOR, B. FIBRINOGEN AND C. A PLASMINOGEN, SUCH AS THE PLASMINOGEN OF A RUMINANT, E.G. BOVINE PLASMINOGEN, WHICH CANNOT BE ACTIVATED BY THE CATALYST AND D.
Inventors
- 👤 Hermann Erich Karges
- 👤 Norbert Heimburger
- 👤 Eckart Jacobi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:29
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/56; G; G01; G01N; G01N2333/00; G01N2333/90; G01N2333/914; G01N2333/948; G01N2333/968
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
41 words
A method for the analytical determination of human plasminogen, which comprises mixing a liquid containing diluted human plasminogen with (a) streptokinase, (b) fibrinogen, (c) the plasminogen of a ruminant, and (d) thrombin, and then determining the coagulation time of the mixture.
Claim 2
Independent Claim
41 words
A method for the analytical determination of human plasminogen, which comprises mixing a liquid containing diluted human plasminogen with (a) streptokinase, (b) fibrinogen, (c) the plasminogen of a ruminant, and (d) thrombin, and then determining the coagulation time of the mixture.
Claim 3
Dependent Claim
48 words
A method as in claim 1 wherein streptokinase is added to a diluted body liquid containing human plasminogen, the mixture is added to a solution containing fibrinogen and the plasminogen of a ruminant, this second mixture is brought to coagulation with thrombin, and the coagulation time is determined.
Claim 4
Dependent Claim
46 words
A method as in claim 1 wherein a diluted body liquid containing human plasminogen is added to a mixture of (a) streptokinase, (b) fibrinogen, and (c) the plasminogen of a ruminant, the resultant mixture is brought to coagulation with thrombin, and the coagulation time is determined.
Claim 5
Dependent Claim
33 words
A method as in claim 1 wherein 250 to 5,000 units of streptokinase, as defined by Christensen, are mixed per milliliter of an aqueous solution of a body fluid pre-diluted 1:5 to 1:1500.
Claim 6
Dependent Claim
15 words
A method as in claim 1 wherein said plasminogen of a ruminant is bovine plasminogen.
Claim 7
Dependent Claim
26 words
A reagent for the determination of human plasminogen, said reagent consisting essentially of (a) streptokinase, (b) fibrinogen, (c) the plasminogen of a ruminant, and (d) thrombin.
Claim 8
Dependent Claim
26 words
A reagent for the determination of human plasminogen, said reagent consisting essentially of (a) streptokinase, (b) fibrinogen, (c) the plasminogen of a ruminant, and (d) thrombin.
Claim 9
Dependent Claim
21 words
A reagent as in claim 6 wherein said fibrinogen is bovine fibrinogen and said plasminogen of a ruminant is bovine plasminogen.
References Cited (Backward Citations)
US3853710A
Cited
US3778352A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-04 | 1981-01-03 | 1981-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-04 | 1985-01-03 | 1985-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-04 | 1989-01-03 | 1989-07-05 | $7700.00 | Window Closed / Lapsed |