US4031892A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Two-chamber mixing syringe
Assignee: AMPOULES CORP
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Filing: 1976-02-13
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Granted: 1977-06-28
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Expires: 1996-02-13
Abstract
Abstract Two-chamber syringes for mixing a powdered medicament with a diluent and then injecting the mixed ingredients into a patient are disclosed, together with a technique for assembling those syringes. According to one aspect of the invention, the syringe includes a vial formed with a single glass cylinder closed at one end by a plunger and at its other end by a pierceable diaphragm. An intermediate pierceable diaphragm divides the cylinder into upper and lower chambers, and is locked against axial movement relative to the cylinder. A powdered medicament is provided in the upper chamber and a diluent is provided in the lower chamber. The ingredients are mixed by inserting the vial into a cup-shaped holder having a hollow, pointed needle extending from the base of the holder. Axial pressure on the vial causes the pointed end of the needle to sequentially pierce the end and intermediate diaphragms, and to cause the diluent to flow into an opening in the sidewall of the needle, through the needle, and then into the upper chamber from the pointed needle end. The thus-mixed ingredients are dispensed by applying axial pressure to the plunger, or by drawing metered amounts into the medicament pressurizing chamber of a needleless, hypojet injector.
Inventors
- 👤 Alfred A. Hurschman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:39
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/14; A61J1/20; A61J1/2093; A61M; A61M5/00; A61M5/178; A61M5/24; A61M5/2448; A61J1/2003; A61J1/2006; A61J1/201; A61J1/2013; A61M5/31; A61M2005/3103; A61M2005/3107; A61M2005/3109; A61M5/1782; A61M5/2455; A61M5/2459; A61M5/30; A61M5/3145; A61M5/315; A61M5/31501; A61M5/31505; A61M5/32; A61M5/3202
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
98 words
A two-chamber mixing vial comprising: (a) a glass cylinder; (b) closure means closing one end of said cylinder; (c) an end diaphragm closing the other end of said cylinder; and (d) a stationary intermediate diaphragm within said cylinder separating the interior of the cylinder into first and second chambers respectively defined by said closure means and intermediate diaphragm and by said intermediate diaphragm and end diaphragm; said cylinder and intermediate diaphragm having coacting parts that comprise means for locking the intermediate diaphragm against axial movement toward the said plunger during a mixing operation and during a dispensing operation.
Claim 2
Dependent Claim
98 words
A two-chamber mixing vial comprising: (a) a glass cylinder; (b) closure means closing one end of said cylinder; (c) an end diaphragm closing the other end of said cylinder; and (d) a stationary intermediate diaphragm within said cylinder separating the interior of the cylinder into first and second chambers respectively defined by said closure means and intermediate diaphragm and by said intermediate diaphragm and end diaphragm; said cylinder and intermediate diaphragm having coacting parts that comprise means for locking the intermediate diaphragm against axial movement toward the said plunger during a mixing operation and during a dispensing operation.
Claim 3
Dependent Claim
19 words
A two-chamber mixing vial according to claim 1 wherein said closure means comprises a plunger slidable within said cylinder.
Claim 4
Dependent Claim
30 words
A two-chamber mixing vial according to claim 1 wherein said one end of said cylinder comprises a bottle neck and wherein said closure means comprises a stopper within said neck.
Claim 5
Dependent Claim
28 words
A two-chamber mixing vial according to claim 1 wherein said coacting parts lock said intermediate diaphragm against axial movement toward said closure means and toward said intermediate diaphragm.
Claim 6
Dependent Claim
31 words
A two-chamber mixing vial according to claim 4 wherein said coacting parts include an inwardly extending circumferential rib in the cylinder which cooperates with a circumferential recess in said intermediate diaphragm.
Claim 7
Dependent Claim
102 words
A two-chamber mixing syringe comprising: (a) vial means, said vial means comprising first and second cylinders; (b) a plunger slidable within and closing one end of the first cylinder; (c) intermediate diaphragm means closing the other end of said first cylinder and closing one end of said second cylinder, said intermediate diaphragm means having a radially extending annular flange against which said other end and said one end are butted to lock said intermediate diaphragm means against movement toward said plunger; (d) an end diaphragm closing the other end of said second cylinder; and (e) a sleeve telescopingly receiving said vial means.
Claim 8
Dependent Claim
102 words
A two-chamber mixing syringe comprising: (a) vial means, said vial means comprising first and second cylinders; (b) a plunger slidable within and closing one end of the first cylinder; (c) intermediate diaphragm means closing the other end of said first cylinder and closing one end of said second cylinder, said intermediate diaphragm means having a radially extending annular flange against which said other end and said one end are butted to lock said intermediate diaphragm means against movement toward said plunger; (d) an end diaphragm closing the other end of said second cylinder; and (e) a sleeve telescopingly receiving said vial means.
Claim 9
Dependent Claim
22 words
A two-chamber mixing syringe according to claim 6 wherein said intermediate diaphragm means comprises first and second diaphragms which are butted together.
Claim 10
Dependent Claim
96 words
A two-chamber mixing syringe comprising: (a) vial means, said vial means comprising first and second vials each having a neck at one end thereof; (b) a plunger slidable within and closing the other end of said first vial; (c) intermediate diaphragm means closing the necked end of said first vial and the necked end of said second vial, said intermediate diaphragm means having a radially extending flange against which the necked end of each vial butts; (d) means banding said neck ends together; and (e) an end diaphragm closing the other end of said second vial.
Claim 11
Dependent Claim
96 words
A two-chamber mixing syringe comprising: (a) vial means, said vial means comprising first and second vials each having a neck at one end thereof; (b) a plunger slidable within and closing the other end of said first vial; (c) intermediate diaphragm means closing the necked end of said first vial and the necked end of said second vial, said intermediate diaphragm means having a radially extending flange against which the necked end of each vial butts; (d) means banding said neck ends together; and (e) an end diaphragm closing the other end of said second vial.
Claim 12
Dependent Claim
22 words
A two-chamber mixing syringe according to claim 8 wherein said intermediate diaphragm means comprises first and second diaphragms which are butted together.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-27 | 1980-12-27 | 1981-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-27 | 1984-12-27 | 1985-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-27 | 1988-12-27 | 1989-06-28 | $7700.00 | Window Closed / Lapsed |