US4031209A
Expired / Lapsed
US
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Aqueous solution suitable for dissipating available iodine contained in an iodophor
Assignee: Wesley Jessen Inc
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Filing: 1975-06-02
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Granted: 1977-06-21
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Expires: 1995-06-02
Abstract
Abstract An aqueous solution suitable for dissipating, at a controlled rate, available iodine contained in an iodophor is disclosed. The aqueous dissipating solution contains sorbic acid or soluble salts thereof and ethylenediaminetetraacetic acid or soluble salts thereof. Preferably, the dissipating solution also contains an ammonium, alkali metal, or alkaline earth metal salt of a boron oxyacid. Also disclosed are techniques for sterilizing contact lenses and sterile solutions, suitable for maintaining sterility of a previously sterilized object, comprising admixtures of the dissipating solutions with iodophor solutions.
Inventors
- 👤 Joseph Zenon Krezanoski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:34
CPC Classifications
A; A61; A61L; A61L12/00; A61L12/08; A61L12/10; A61L12/105; A61K; A61K33/00; A61K33/22; C; C11; C11D; C11D3/00; C11D3/0005; C11D3/0078
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
53 words
A sterile aqueous solution suitable for dissipating available iodine contained in an iodophor at a controlled rate, consisting essentially of: a. from about 0.01% to about 5% by weight sorbic acid or a soluble salt thereof; and b. from about 0.01% to about 5% by weight ethylenediaminetetraacetic acid or a soluble salt thereof.
Claim 2
Dependent Claim
53 words
A sterile aqueous solution suitable for dissipating available iodine contained in an iodophor at a controlled rate, consisting essentially of: a. from about 0.01% to about 5% by weight sorbic acid or a soluble salt thereof; and b. from about 0.01% to about 5% by weight ethylenediaminetetraacetic acid or a soluble salt thereof.
Claim 3
Dependent Claim
28 words
The solution of claim 1 which additonally contains from about 0.1% to about 2% of an ammonium, alkali metal or alkaline earth metal salt of a boron oxyacid.
Claim 4
Dependent Claim
11 words
The solution of claim 2 wherein said salt is sodium borate.
Claim 5
Dependent Claim
27 words
The solution of claim 2 which additionally contains up to about 2% of a water soluble alkali metal or alkaline earth metal salt of a mineral acid.
Claim 6
Dependent Claim
126 words
A sterile aqueous solution comprising an admixture of a. from about 1% to about 10% by weight of an aqueous iodophor solution comprising from about 0.00005% to about 10% by weight iodine, from about 0.0001% to about 20% by weight of a water soluble iodide salt or hydriotic acid, and from about 0.001% to about 25% by weight polyvinyl alcohol; and b. from about 90% to about 99% by weight of a sterile aqueous solution comprising from about 0.01% to about 5% by weight sorbic acid or a soluble salt thereof; from about 0.01% to about 5% by weight ethylenediaminetetraacetic acid or a soluble salt thereof; and about 0.1% to about 2% of an ammonium, alkali metal, or alkaline earth metal salt of a boron oxyacid.
Claim 7
Dependent Claim
126 words
A sterile aqueous solution comprising an admixture of a. from about 1% to about 10% by weight of an aqueous iodophor solution comprising from about 0.00005% to about 10% by weight iodine, from about 0.0001% to about 20% by weight of a water soluble iodide salt or hydriotic acid, and from about 0.001% to about 25% by weight polyvinyl alcohol; and b. from about 90% to about 99% by weight of a sterile aqueous solution comprising from about 0.01% to about 5% by weight sorbic acid or a soluble salt thereof; from about 0.01% to about 5% by weight ethylenediaminetetraacetic acid or a soluble salt thereof; and about 0.1% to about 2% of an ammonium, alkali metal, or alkaline earth metal salt of a boron oxyacid.
Claim 8
Dependent Claim
26 words
The aqueous solution of claim 5 in which the pH of said iodophor solution is adjusted to be within the range of about 3 to 8.
Claim 9
Dependent Claim
34 words
The process of claim 6 in which said pH is adjusted with an acid selected from the group consisting of H 3 PO 4 , HCl, acetic, H 2 SO 4 , and nitric.
Claim 10
Dependent Claim
18 words
The aqueous solution of claim 6 in which said iodophor solution has a pH of less than 7.
Claim 11
Dependent Claim
46 words
The aqueous solution of claim 5 in which said iodophor solution contains from about 0.002% to about 5% by weight iodine, about 0.004% to about 10% by weight water soluble iodide salt or hydriotic acid, and from about 0.1% to about 20% by weight polyvinyl alcohol.
Claim 12
Dependent Claim
28 words
The aqueous solution of claim 5 in which said iodophor solution includes a water soluble iodide salt selected from the group consisting of potassium iodide and sodium iodide.
Claim 13
Dependent Claim
29 words
The aqueous solution of claim 5 in which the tonicity of said iodophor solution is adjusted to the equivalent of a 0.1% to a 5% aqueous sodium chloride solution.
Claim 14
Dependent Claim
29 words
The aqueous solution of claim 11 in which the tonicity is adjusted by the addition of appropriate amounts of alkali metal and alkaline earth metal salts of mineral acids.
Claim 15
Dependent Claim
22 words
The aqueous solution of claim 5 having a viscosity range within the range of from 1.1 to 10,000 cp at 20° C.
Claim 16
Dependent Claim
24 words
The aqueous solution of claim 5 which has a surface tension within the range of from about 40 to about 72 dynes/cm 2 .
Claim 17
Dependent Claim
40 words
A method of dissipating available iodine contained in an iodophor comprising adding to said iodophor, in an amount of from 1 to 1000 parts by weight per part of available iodine in said iodophor, the aqueous solution of claim 1.
Claim 18
Dependent Claim
40 words
A method of dissipating available iodine contained in an iodophor comprising adding to said iodophor, in an amount of from 1 to 1000 parts by weight per part of available iodine in said iodophor, the aqueous solution of claim 2.
Claim 19
Independent Claim
165 words
A method of sterilizing contact lenses comprising: a. contacting said lens with an aqueous antiseptic iodophor solution comprising from about 0.00005% to about 10% by weight iodine, from about 0.0001% to about 20% by weight of a water soluble iodide salt or hydriotic acid, and from about 0.001% to about 25% by weight polyvinyl alcohol; and b. dissipating available iodine contained in said iodophor by adding to said aqueous iodophor solution in an amount of from about 90% to about 99% by weight based on the total weight of the combined solutions, an antioxidant having a redox potential adequate to convert I 2 to 2I - , which antioxidant comprises an aqueous dissipating solution comprising from about 0.01% to about 5% by weight sorbic acid or a soluble salt thereof; from about 0.01% to about 5% by weight ethylenediaminetetraacetic acid or a soluble salt thereof; and about 0.1% to about 2% of an ammonium, alkali metal, or alkaline earth metal salt of a boron oxyacid.
Claim 20
Independent Claim
165 words
A method of sterilizing contact lenses comprising: a. contacting said lens with an aqueous antiseptic iodophor solution comprising from about 0.00005% to about 10% by weight iodine, from about 0.0001% to about 20% by weight of a water soluble iodide salt or hydriotic acid, and from about 0.001% to about 25% by weight polyvinyl alcohol; and b. dissipating available iodine contained in said iodophor by adding to said aqueous iodophor solution in an amount of from about 90% to about 99% by weight based on the total weight of the combined solutions, an antioxidant having a redox potential adequate to convert I 2 to 2I - , which antioxidant comprises an aqueous dissipating solution comprising from about 0.01% to about 5% by weight sorbic acid or a soluble salt thereof; from about 0.01% to about 5% by weight ethylenediaminetetraacetic acid or a soluble salt thereof; and about 0.1% to about 2% of an ammonium, alkali metal, or alkaline earth metal salt of a boron oxyacid.
Claim 21
Dependent Claim
23 words
The method of claim 17 in which said aqueous antiseptic iodophor solution has a pH within the range of about 3 to 7.
Claim 22
Dependent Claim
14 words
The method of claim 17 in which said lens is a hydrophilic gel lens.
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