US4031199A
Expired / Lapsed
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Process for the production of allergen-containing extracts
Assignee: Merck Patent GmbH
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Filing: 1975-12-15
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Granted: 1977-06-21
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Expires: 1995-12-15
Abstract
Abstract Improved allergen-containing extracts are obtained by the extraction of allergy-causing materials, such as pollen and house dust, with hydrophilic aqueous extractants, by pretreating the allergen-containing material with a lipophilic, aqueous extraction liquid. Allergens extracted in the two steps can be combined and formed into allergen preparations, which can be used both for diagnostic and therapeutic purposes.
Inventors
- 👤 Otto Nieschulz
- 👤 Gunther Rudiger
- 👤 Jurgen Maass
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:03
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
107 words
In a process for preparing an allergen extract which includes pre-extracting an allergen-containing material having a plurality of allergens, a portion of which is more lipophilic in character than the remainder, with a lipophilic solvent consisting essentially of an aqueous solution of a neutral, water-soluble cyclic ether having a boiling point below 105° C. which is at least one member selected from the group consisting of tetrahydrofuran, tetrahydropyran and dioxane to extract said lipophilic portion; extracting resultant allergen-containing material with a hydrophilic aqueous or aqueous alcoholic allergen solvent; and recovering water-soluble allergens from said material; the improvement which comprises: sonicating said allergen-containing material to increase allergenic activity.
Claim 2
Dependent Claim
107 words
In a process for preparing an allergen extract which includes pre-extracting an allergen-containing material having a plurality of allergens, a portion of which is more lipophilic in character than the remainder, with a lipophilic solvent consisting essentially of an aqueous solution of a neutral, water-soluble cyclic ether having a boiling point below 105° C. which is at least one member selected from the group consisting of tetrahydrofuran, tetrahydropyran and dioxane to extract said lipophilic portion; extracting resultant allergen-containing material with a hydrophilic aqueous or aqueous alcoholic allergen solvent; and recovering water-soluble allergens from said material; the improvement which comprises: sonicating said allergen-containing material to increase allergenic activity.
Claim 3
Dependent Claim
26 words
A process according to claim 1, wherein said allergen-containing material is selected from the group consisting of allergenic pollens, seeds, house dust, epithelia, fungi and insects.
Claim 4
Dependent Claim
17 words
A process according to claim 1, wherein ultrasonic sound having a frequency of 20-30 kilohertz is employed.
Claim 5
Dependent Claim
22 words
A process according to claim 1, wherein ultrasonic treatment is conducted during extraction with said hydrophilic aqueous or aqueous alcoholic allergen solvent.
Claim 6
Dependent Claim
50 words
A process according to claim 1, wherein said allergen-containing material is selected from the group consisting of allergenic pollens, seeds, house dust, epithelia, fungi and insects and ultrasonic treatment is conducted during extraction with said hydrophilic aqueous or aqueous alcholic solvent employing ultrasonic sound having a frequency of 20-30 kilohertz.
Claim 7
Dependent Claim
11 words
An allergen-containing extract prepared according to the process of claim 5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-20 | 1980-12-20 | 1981-06-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-20 | 1984-12-20 | 1985-06-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-20 | 1988-12-20 | 1989-06-21 | $7700.00 | Window Closed / Lapsed |