US4029878A
Expired / Lapsed
US
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Process for preparing mannitol from glucose
Assignee: Zeneca Inc
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Filing: 1975-05-19
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Granted: 1977-06-14
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Expires: 1995-05-19
Abstract
Abstract Mannose is produced from a concentrated solution of glucose or polymers of glucose in the presence of a catalyst containing hexavalent molybdenum. Subsequent hydrogenation of the product in order to produce mannitol is also disclosed.
Inventors
- 👤 Walter M. Kruse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 05:44
CPC Classifications
C; C07; C07C; C07C31/00; C07C31/18; C07C31/26; C07H; C07H3/00; C07H3/02; C13; C13K; C13K13/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
67 words
In a process for producing a solution containing glucose and mannose by contacting an acidic solution of glucose, oligomers of glucose, or a mixture of glucose and oligomers thereof, with a catalyst containing molybdenum in the hexavalent state at a temperature of at least about 70° C. under non-hydrogenating conditions, the improvement wherein said solution has a carbohydrate content of at least about 50 percent by weight.
Claim 2
Dependent Claim
67 words
In a process for producing a solution containing glucose and mannose by contacting an acidic solution of glucose, oligomers of glucose, or a mixture of glucose and oligomers thereof, with a catalyst containing molybdenum in the hexavalent state at a temperature of at least about 70° C. under non-hydrogenating conditions, the improvement wherein said solution has a carbohydrate content of at least about 50 percent by weight.
Claim 3
Dependent Claim
14 words
A process according to claim 1 in which the solution is an aqueous solution.
Claim 4
Dependent Claim
20 words
A process according to claim 2, in which the pH of the solution is from about 3 to about 5.
Claim 5
Dependent Claim
15 words
A process according to claim 1 in which the solvent is a polar organic solvent.
Claim 6
Dependent Claim
13 words
A process according to claim 1 in which glucose is the starting material.
Claim 7
Dependent Claim
21 words
A process according to claim 1 in which the starting material is a carbohydrate consisting essentially of glucose and oligomers thereof.
Claim 8
Dependent Claim
14 words
A process according to claim 6 in which the starting material is cornstarch hydrolyzate.
Claim 9
Dependent Claim
22 words
A process according to claim 1 in which the reaction temperature is in the range of about 85° to about 160° C.
Claim 10
Dependent Claim
25 words
A process according to claim 1 in which the amount of catalyst is at least about 0.05% by weight, based on the weight of carbohydrate.
Claim 11
Dependent Claim
13 words
A process according to claim 1, in which the catalyst is molybdic acid.
Claim 12
Dependent Claim
14 words
A process according to claim 1, in which catalyst is an alkali metal phosphomolybdate.
Claim 13
Dependent Claim
16 words
A process according to claim 1, in which the catalyst comprises molybdenum on an ion-exchange resin.
Claim 14
Dependent Claim
23 words
A process according to claim 1 comprising the further step of removing of the molybdenum catalyst from the solution of glucose and mannose.
Claim 15
Dependent Claim
43 words
A process according to claim 1 including the further steps of hydrogenating said solution of glucose and mannose at an elevated temperature in the presence of an hydrogenation catalyst, thereby producing a solution containing sorbitol and mannitol, and recovering mannitol from said solution.
Claim 16
Dependent Claim
14 words
A process according to claim 14 in which the solution is an aqueous solution.
Claim 17
Dependent Claim
15 words
A process according to claim 14 in which the hydrogenation catalyst is a nickel catalyst.
Claim 18
Dependent Claim
23 words
A process according to claim 16 in which said solution of glucose and mannose is hydrogenated without prior removal of said molybdenum catalyst.
Claim 19
Dependent Claim
33 words
A process according to claim 14 in which the hydrogenation catalyst is a ruthenium catalyst and in which the molybdenum catalyst is separated from the solution of glucose and mannose prior to hydrogenation.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |