US4029795A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4(2' Isoquinolin-1-one)piperidines
Assignee: Novartis Corp
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Filing: 1975-07-14
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Granted: 1977-06-14
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Expires: 1995-07-14
Abstract
Abstract 1-(3-Aryloxy-2-hydroxypropyl)-4-(1-oxoisoquinolino)-piperidines, e.g. those of the formula ##STR1## R' = H, alkanoylaminoethenyl, carbamoyl, alkanoyl, CN, alkoxycarbonylamino-lower alkyl, halo, OH, alkanoylamino, alkyl, alkoxy, alkenyl, alkenyloxy R" = H, alkyl, alkoxy, alkenyl, alkenyloxy, R'" = alkanoylamino, NH 2 , NO 2 , alkyl, alkoxy, halo CF 3 , OH 2-alkanoic acid esters and acid addition salts thereof are antihypertensive and antiarrhythmic agents.
Inventors
- 👤 Kurt Eichenberger
- 👤 Christian Egli
- 👤 Hans Kuhnis
- 👤 Oswald Schier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:22
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/74
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
91 words
A 1-(3-aryloxy-2-hydroxy- or 2-alkanoyloxy-propyl)-4-(1-oxoisoquinolino)-piperidine compound corresponding to formula ##STR26## wherein R' and R" are hydrogen, lower o-alkyl, lower o-alkenyl, lower o-alkoxy, lower o-alkenyloxy or an o-halogen atom and R' and R" together with the phenyl radical form a β-naphthyl radical, R 2 ' denotes hydrogen or lower alkanoyl, R 3 denotes hydrogen, R 4 , R 5 and R 6 denote hydrogen, R'" denotes hydrogen, lower alkyl, lower alkoxy, halogen, or trifluoromethyl, or a therapeutically useful acid addition salt thereof, wherein said open chain groups have up to 4 carbon atoms.
Claim 2
Dependent Claim
91 words
A 1-(3-aryloxy-2-hydroxy- or 2-alkanoyloxy-propyl)-4-(1-oxoisoquinolino)-piperidine compound corresponding to formula ##STR26## wherein R' and R" are hydrogen, lower o-alkyl, lower o-alkenyl, lower o-alkoxy, lower o-alkenyloxy or an o-halogen atom and R' and R" together with the phenyl radical form a β-naphthyl radical, R 2 ' denotes hydrogen or lower alkanoyl, R 3 denotes hydrogen, R 4 , R 5 and R 6 denote hydrogen, R'" denotes hydrogen, lower alkyl, lower alkoxy, halogen, or trifluoromethyl, or a therapeutically useful acid addition salt thereof, wherein said open chain groups have up to 4 carbon atoms.
Claim 3
Dependent Claim
62 words
A compound as claimed in claim 1, corresponding to formula Ia, wherein R' denotes lower o-alkenyl, lower o-alkenyloxy, lower o-alkyl, or lower o-alkoxy, R" represents hydrogen, R 2 ' denotes acetyl, propionyl, pivaloyl, or hydrogen, R 3 denotes a hydrogen, and R 4 , R 5 , R 6 and R'" each denote hydrogen or a therapeutically useful acid addition salt thereof.
Claim 4
Dependent Claim
58 words
A compound as claimed in claim 1, corresponding to formula Ia, wherein R' denotes o-allyl, o-allyloxy, o-methyl or o-methoxy, R" represents hydrogen, R 2 ' denotes the acetyl, propionyl, pivaloyl, or hydrogen, R 3 denotes a hydrogen, and R 4 , R 5 , R 6 and R'" denote hydrogen, or a therapeutically useful acid addition salt thereof.
Claim 5
Dependent Claim
18 words
A compound as claimed in claim 1 and being 2-{1-[3-(o-Allyloxyphenoxy)-2-hydroxypropyl]-4-piperidyl}-3,4-dihydro-1(2H)-isoquinolinone and a therapeutically useful acid addition salt thereof.
Claim 6
Dependent Claim
18 words
A compound as claimed in claim 1 and being 2-{1-[3-(o-chlorophenoxy)-2-hydroxypropyl]-4-piperidyl}-3,4-dihydro-1(2H)-isoquinolinone and a therapeutically useful acid addition salt thereof.
Claim 7
Dependent Claim
18 words
A compound as claimed in claim 1 and being 2-{1-[3-(o-methoxyphenoxy)-2-pivaloyloxy-propyl]-4-piperidyl}-3,4-dihydro-1(2H)-isoquinolinone and a therapeutically useful acid addition salt thereof.
Claim 8
Dependent Claim
18 words
A compound as claimed in claim 1 and being 2-{1-[3-(o-Tolyloxy)-2-hydroxypropyl]-4-piperidyl}-3,4-dihydro-1(2H)-isoquinolinone and a therapeutically useful acid addition salt thereof.
Claim 9
Dependent Claim
18 words
A compound as claimed in claim 1 and being 2-{1-[3-(o-methoxyphenoxy)-2-hydroxypropyl]-4-piperidyl}-3,4-dihydro-1(2H)-isoquinolinone and a therapeutically useful acid addition salt thereof.
Claim 10
Dependent Claim
21 words
An antihypertensive pharmaceutical composition comprising a therapeutically effective amount of a compound claimed in claim 1, together with a pharmaceutical excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |