Patent US6351534B1 successfully refreshed from Google Patents.
US4029790A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Benzoyl-2 or 4 [2-(4-phenyl-piperazino)-ethyl]-piperidines
Assignee: Centre Europeen de Recherches Mauvernay CERM
•
Filing: 1975-09-26
•
Granted: 1977-06-14
•
Expires: 1995-09-26
Abstract
Abstract Compounds of the formula ##STR1## and pharmaceutically acceptable acid salts thereof, wherein X is hydrogen, halogen or methoxy, n is zero, Y is halogen and the ethyl piperazaine moiety is attached to the 2- or 4- position of the piperidine ring, is described. These compounds have anti-spasmolytic and antitussive activity.
Inventors
- 👤 Roland Yves Mauvernay
- 👤 Norbert Busch
- 👤 Jacques Moleyre
- 👤 Jacques Simond
- 👤 Andre Monteil
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 18:08
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
50 words
A compound of the formula: ##STR5## and salts thereof with pharmaceutically acceptable acids in which X represents a hydrogen or halogen atom or methoxy group, n is 0; Y represents a halogen atom; and the ethyl piperazine moiety is attached to the 2- or 4- position of the piperidine ring.
Claim 2
Dependent Claim
50 words
A compound of the formula: ##STR5## and salts thereof with pharmaceutically acceptable acids in which X represents a hydrogen or halogen atom or methoxy group, n is 0; Y represents a halogen atom; and the ethyl piperazine moiety is attached to the 2- or 4- position of the piperidine ring.
Claim 3
Dependent Claim
4 words
1-Benzoyl 2-{2-[4-(4-fluoro)phenyl)piperazinyl} ethyl piperidine.
Claim 4
Dependent Claim
4 words
1-Benzoyl 2-{2-[4-(4-fluoro)phenyl)piperazinyl} ethyl piperidine.
Claim 5
Dependent Claim
5 words
1-(4-Chloro)benzoyl 2-{(2-[4-(4-fluoro)phenyl] piperazinyl} ethyl piperidine.
Claim 6
Dependent Claim
5 words
1-(4-Chloro)benzoyl 2-{(2-[4-(4-fluoro)phenyl] piperazinyl} ethyl piperidine.
Claim 7
Dependent Claim
3 words
1-(4-Fluoro)benzoyl 2-{2-[4-(4-fluoro)phenyl]piperazinyl}ethyl piperidine.
Claim 8
Dependent Claim
3 words
1-(4-Fluoro)benzoyl 2-{2-[4-(4-fluoro)phenyl]piperazinyl}ethyl piperidine.
Claim 9
Dependent Claim
4 words
1-(4-Chloro)benzoyl 4-{2-[ 4-(4-chloro)phenyl]piperazinyl}ethyl piperidine.
Claim 10
Dependent Claim
4 words
1-(4-Chloro)benzoyl 4-{2-[ 4-(4-chloro)phenyl]piperazinyl}ethyl piperidine.
Claim 11
Dependent Claim
5 words
1-(4-Chloro)benzoyl 4-{ 2-[4-(4-fluoro)phenyl]piperazinyl} ethyl piperidine.
Claim 12
Dependent Claim
5 words
1-(4-Chloro)benzoyl 4-{ 2-[4-(4-fluoro)phenyl]piperazinyl} ethyl piperidine.
Claim 13
Dependent Claim
6 words
1-(-Fluoro)benzoyl 4-{ 2[ 4-[ 4-fluoro)phenyl]piperzinyl}ethyl piperidine.
Claim 14
Dependent Claim
6 words
1-(-Fluoro)benzoyl 4-{ 2[ 4-[ 4-fluoro)phenyl]piperzinyl}ethyl piperidine.
Claim 15
Dependent Claim
65 words
A pharmaceutical composition consisting essentially of a compound of ##STR6## and salts thereof with pharmaceutically acceptable acids in which X represents a hydrogen or halogen atom or a lower alkoxy group, n is 0; Y represents a halogen atom; and the ethyl piperazine moiety is attached to the 2- or 4- position of the piperidine ring in association with a pharmaceutically acceptable carrier or diluent.
Claim 16
Dependent Claim
65 words
A pharmaceutical composition consisting essentially of a compound of ##STR6## and salts thereof with pharmaceutically acceptable acids in which X represents a hydrogen or halogen atom or a lower alkoxy group, n is 0; Y represents a halogen atom; and the ethyl piperazine moiety is attached to the 2- or 4- position of the piperidine ring in association with a pharmaceutically acceptable carrier or diluent.
Claim 17
Independent Claim
71 words
A method of treating bronchospasmolytic and tussive conditions by administering a formula: ##STR7## or pharmaceutically acceptable acid salts thereof in which X represents a hydrogen or halogen atom or methoxy group, n is 0; Y represents a halogen atom; and the ethyl piperazine moiety is attached to the 2- or 4- position of the piperidine ring in dosages of from 10 to 500 mg per day in an orally acceptable form.
Claim 18
Independent Claim
71 words
A method of treating bronchospasmolytic and tussive conditions by administering a formula: ##STR7## or pharmaceutically acceptable acid salts thereof in which X represents a hydrogen or halogen atom or methoxy group, n is 0; Y represents a halogen atom; and the ethyl piperazine moiety is attached to the 2- or 4- position of the piperidine ring in dosages of from 10 to 500 mg per day in an orally acceptable form.
References Cited (Backward Citations)
US3729474A
Cited
US3753985A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |