US4029672A
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Aminoalkylpyrrolobenzoxazalkanes
Assignee: CNA Holdings LLC
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Filing: 1976-02-26
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Granted: 1977-06-14
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Expires: 1996-02-26
Abstract
Abstract Novel aminoalkylpyrrolobenzoxazalkanes, physiologically tolerable acid addition salts thereof, method of preparing same and novel intermediates in the preparation thereof are described. These compounds are useful as analgesic agents and tranquilizers.
Inventors
- 👤 Richard C. Effland
- 👤 Larry Davis
- 👤 Wolfgang Schaub
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:10
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/32; C07D207/33; C07D207/333; A; A61; A61P; A61P25/00; A61P25/04; A61P25/08; A61P25/20; A61P29/00; C07D207/335
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
148 words
A compound of the formula wherein Y is hydrogen, halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, trifluoromethyl, nitro or amino; R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; R 2 is hydrogen, alkyl of from 1 to 5 carbon atoms, phenyl, cycloalkyl of from 3 to 6 carbon atoms, phenalkyl of the formula C 6 H 5 (CH 2 ) n --, or cycloakylalkyl of from 4 to 7 carbon atoms; R 3 is alkyl of from 1 to 5 carbon atoms, phenyl, cycloalkyl of from 3 to 6 carbon atoms, phenalkyl of the formula C 6 H 5 (CH 2 ) n --or cycloalkylalkyl of from 4 to 7 carbon atoms; m is the integer 1 or 2 and n is the integer 1, 2 or 3, or a physiologically tolerable acid addition salt thereof.
Claim 2
Dependent Claim
148 words
A compound of the formula wherein Y is hydrogen, halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, trifluoromethyl, nitro or amino; R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; R 2 is hydrogen, alkyl of from 1 to 5 carbon atoms, phenyl, cycloalkyl of from 3 to 6 carbon atoms, phenalkyl of the formula C 6 H 5 (CH 2 ) n --, or cycloakylalkyl of from 4 to 7 carbon atoms; R 3 is alkyl of from 1 to 5 carbon atoms, phenyl, cycloalkyl of from 3 to 6 carbon atoms, phenalkyl of the formula C 6 H 5 (CH 2 ) n --or cycloalkylalkyl of from 4 to 7 carbon atoms; m is the integer 1 or 2 and n is the integer 1, 2 or 3, or a physiologically tolerable acid addition salt thereof.
Claim 3
Dependent Claim
17 words
A compound as defined in claim 1 of the formula ##STR4## wherein Y is hydrogen or halogen.
Claim 4
Dependent Claim
13 words
A compound as defined in claim 1 wherein m is the integer 1.
Claim 5
Dependent Claim
13 words
A compound as defined in claim 1 wherein m is the integer 2.
Claim 6
Dependent Claim
74 words
A compound as defined in claim 1 wherein Y is hydrogen chlorine; R 1 is hydrogen, methyl, ethyl or propyl; R 2 is hydrogen or straight or branched chain alkyl of from 1 to 4 carbon atoms; R 3 i straight or branched chain alkyl of from 1 to 4 carbon atoms, phenyl, phenalkyl of the formula C 6 H 5 (CH 2 ) n -or cycloalkyl of from 3 to 6 carbon atoms.
Claim 7
Dependent Claim
11 words
A compound as defined in claim 5 wherein n is 1.
Claim 8
Dependent Claim
11 words
A compound as defined in claim 5 wherein n is 2.
Claim 9
Dependent Claim
11 words
A compound as defined in claim 5 wherein n is 3.
Claim 10
Dependent Claim
16 words
A compound as defined in claim 1 wherein R 1 is hydrogen and n is 1.
Claim 11
Dependent Claim
10 words
The compound as defined in claim 1 which is 4-(ethylaminomethyl)-4H,10H-pyrrolo[2,1-c][1,4]benzoxazepine.
Claim 12
Dependent Claim
10 words
The compound as defined in claim 1 which is 4-(methylaminomethyl)-4H,10H-pyrrolo[2,1-c][1,4]benzoxazepine.
Claim 13
Dependent Claim
10 words
The compound as defined in claim 1 which is 4-(cyclopropylaminomethyl)-4H,10H-pyrrolo[2,1-c][1,4]benzoxazepine.
Claim 14
Dependent Claim
10 words
The compound as defined in claim 1 which is 4-(dimethylaminomethyl)-4H,10H-pyrrolo[2,1-c][1,4]benzoxazepine.
Claim 15
Dependent Claim
10 words
The compound as defined in claim 1 which is 4-(diethyl)aminomethyl)-4H,10H-pyrrolo[2,1-c][1,4]benzoxazepine.
Claim 16
Dependent Claim
22 words
The method of treating pain which comprises administering to a patient a pharmaceutically effective amount of a compound defined in claim 1.
Claim 17
Dependent Claim
25 words
A method of depressing the central nervous system which comprises administering to a patient a pharmaceutically effective amount of a compound defined in claim 1.
Claim 18
Dependent Claim
22 words
A method of treating convulsions which comprises administering to a patient a pharmaceutically effective amount of a compound defined in claim 1.
Claim 19
Dependent Claim
45 words
A pharmaceutical composition for treating pain or convulsions of depressing the central nervous system which comprises between about 0.5 and about 70 percent by weight of a compound defined in claim 1 as an essential active ingredient, the balance being a pharmaceutically accceptable carrier therefor.
References Cited (Backward Citations)
JPS4812756B1
Cited
DE2306605A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |