US4027023A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cinnolin-3-yl carboxylic acids and derivatives
Assignee: Imperial Chemical Industries Ltd
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Filing: 1975-07-28
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Granted: 1977-05-31
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Expires: 1995-07-28
Abstract
Abstract Cinnolin-3-yl carboxylic acids and esters, amides and like derivatives, processes for the preparation of these compounds, and pharmaceutical compositions comprising any one of these compounds. A representative compound is ethyl 6-ethylcinnolin-3-yl carboxylate. The compounds are active as inhibitors of effects following the combination of reagin-like antibodies and their antigens.
Inventors
- 👤 John Preston
- 👤 Michael John Cooper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 22:58
CPC Classifications
C; C07; C07D; C07D237/00; C07D237/26; C07D237/28; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
68 words
A pharmaceutical composition for the treatment of a syndrome or disease initiated by an antigen-antibody reaction comprising an effective amount of a compound of the formula: ##STR5## wherein R 1 stands for hydroxy, methoxy, ethoxy, 2-diethylaminoethoxy, phenoxy, hydroxyamino or 1,2,3,4-tetrazol-5-ylamino, and R 2 stands for ethyl, n-propyl, cyclohexyl, amino, acetylamino, phenyl, p-chlorophenyl, dinitrophenyl, chloro or bromo, or a pharmaceutically-acceptable salt thereof, and an inert pharmaceutically-acceptable diluent or carrier.
Claim 2
Dependent Claim
68 words
A pharmaceutical composition for the treatment of a syndrome or disease initiated by an antigen-antibody reaction comprising an effective amount of a compound of the formula: ##STR5## wherein R 1 stands for hydroxy, methoxy, ethoxy, 2-diethylaminoethoxy, phenoxy, hydroxyamino or 1,2,3,4-tetrazol-5-ylamino, and R 2 stands for ethyl, n-propyl, cyclohexyl, amino, acetylamino, phenyl, p-chlorophenyl, dinitrophenyl, chloro or bromo, or a pharmaceutically-acceptable salt thereof, and an inert pharmaceutically-acceptable diluent or carrier.
Claim 3
Dependent Claim
49 words
A compound of the formula: ##STR6## wherein R 1 stands for hydroxy, methoxy, ethoxy, 2-diethylaminoethoxy, phenoxy, hydroxyamino or 1,2,3,4-tetrazol-5-ylamino, and R 2 stands for ethyl, n-propyl, cyclohexyl, amino, acetylamino, phenyl, p-chlorophenyl, dinitrophenyl, chloro or bromo, or a pharmaceutically-acceptable salt thereof, but excluding ethyl 6-chlorocinnolin-3-yl carboxylate and pharmaceutically-acceptable salts thereof.
Claim 4
Dependent Claim
49 words
A compound of the formula: ##STR6## wherein R 1 stands for hydroxy, methoxy, ethoxy, 2-diethylaminoethoxy, phenoxy, hydroxyamino or 1,2,3,4-tetrazol-5-ylamino, and R 2 stands for ethyl, n-propyl, cyclohexyl, amino, acetylamino, phenyl, p-chlorophenyl, dinitrophenyl, chloro or bromo, or a pharmaceutically-acceptable salt thereof, but excluding ethyl 6-chlorocinnolin-3-yl carboxylate and pharmaceutically-acceptable salts thereof.
Claim 5
Dependent Claim
14 words
Composition as claimed in claim 1 which is in an orally-administrable unit dosage form.
Claim 6
Dependent Claim
56 words
A method for the treatment of a syndrome or disease initiated by an antigen-antibody reaction in a host in need of said treatment, which comprises administering to said host a functionally-effective amount of a compound of the formula I as defined in claim 1, or a pharmaceutically-acceptable salt thereof, and an inert pharmaceutically-acceptable diluent or carrier.
Claim 7
Dependent Claim
16 words
Compound as claimed in claim 2 which is 6-bromocinnolin-3-yl carboxylic acid or a pharmaceutically-acceptable salt thereof.
Claim 8
Dependent Claim
16 words
Compound as claimed in claim 2 which is 6-phenylcinnolin-3-yl carboxylic acid or a pharmaceutically-acceptable salt thereof.
Claim 9
Dependent Claim
17 words
A compound as claimed in claim 2 which is 6-chlorocinnolin-3-yl carboxylic acid or a pharmaceutically-acceptable salt thereof.
References Cited (Backward Citations)
US3657241A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-30 | 1980-11-29 | 1981-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-30 | 1984-11-29 | 1985-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-30 | 1988-11-29 | 1989-05-31 | $7700.00 | Window Closed / Lapsed |