Carbamylguanidine antimicrobial compounds

Claim 1

A compound having the formula Z--B--Y--B--Z .sup.. nHA wherein Y is a C 2 -C 12 alkylene, [C 5 -C 12 cycloalkylene, C 5 -C 12 cycloalkylenebis(loweralkyl), C 6 -C 12 arylene and loweralkylarylene, C 7 -C 12 aryleneloweralkyl, and C 8 -C 12 arylenebis(loweralkyl)]; B is a [substituted guandino] carbamylguanidino group [selected from the group consisting of carbamylguanidino and thiocarbamylguanidino]; [or biguanidino provided that B' is biguanidino only when B is carbamylguanidino bonded to Y through the guanidino portion of the group]; and Z is selected from the group consisting of [C 1 -C 12 alkyl; C 4 C 12 dialkylaminoalkyl; C 3 -C 12 alkenyl; C 3 -C 12 alkynyl; C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl; C 1 -C 10 alkoxy C 10 -C 2 alkyl having a total carbon content of C 3 -C 14 ; C 1 -C 10 alkylthio C 10 -C 2 alkyl having a total carbon content of C 3 -c 14 ; phenoxy C 2 -C 6 alkyl; phenylthio C 2 -C 6 alkyl]; C 6 -C 14 aryl; [C 7 -C 14 aralkyl and arylcycloalkyl]; and C 6 -C 14 aryl [and aralkyl]]substituted with one or more radicals selected from the group consisting of lower alkyl, trifluoromethyl, loweralkoxy, trifluoromethyoxy, [phenoxy,] loweralkylthio, halo, [nitro, cyano, C 2 -C 6 acyl, benzoyl, alkoxycarbonyl, diloweralkylamino,] and loweralkylsulfonyl, [fluorosulfonyl and alkylsulfinyl]; and pharmacologically acceptable addition salts of these compounds with acids represented by nHA wherein n=0, 1/3, 1/2, 2/3, 1, and 2 and HA is an inorganic or organic acid.