US4022898A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives
Assignee: Bayer AG
•
Filing: 1975-05-07
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Granted: 1977-05-10
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Expires: 1995-05-07
Abstract
Abstract 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.
Inventors
- 👤 Horst Meyer
- 👤 Friedrich Bossert
- 👤 Wulf Vater
- 👤 Kurt Stoepel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 15:38
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D405/00; C07D405/02; C07D405/04; C07D409/00; C07D409/02; C07D409/04
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
41 words
A compound of the formula: ##STR4## wherein R is pyrimidyl, unsubstituted or substituted by one or two members selected from the group consisting of lower alkyl, lower alkoxy and halogeno; and R 3 is lower alkoxy or lower alkoxy (lower alkoxy).
Claim 2
Dependent Claim
41 words
A compound of the formula: ##STR4## wherein R is pyrimidyl, unsubstituted or substituted by one or two members selected from the group consisting of lower alkyl, lower alkoxy and halogeno; and R 3 is lower alkoxy or lower alkoxy (lower alkoxy).
Claim 3
Dependent Claim
12 words
The compound according to claim 1 which is 2-amino-4-(4,6-dimethoxypyrimid-5-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester.
Claim 4
Dependent Claim
30 words
The method of effecting coronary vessel dilation and a reduction in blood pressure in an animal which comprises administering thereto an effective amount of a compound according to claim 1.
Claim 5
Dependent Claim
32 words
A pharmaceutical composition for use in effecting coronary vessel dilation and a reduction in blood pressure which comprises an effective amount of a compound according to claim 1 and a pharmaceutical carrier.
References Cited (Backward Citations)
US2359329A
Cited
US3544577A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |