Patent US2634292A successfully refreshed from Google Patents.
US4022894A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stable solution of benzthiazide (3-[benzythiol methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) suitable for parenteral administration and process of preparation
Assignee: Individual
•
Filing: 1975-03-03
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Granted: 1977-05-10
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Expires: 1995-03-03
Abstract
Abstract A clear, stable solution of benzthiazide suitable for medical application has benzthiazide dissolved in an aqueous polyethylene glycol vehicle. The solution has a pH in the range of from about 3 to 6. The solution is prepared by mixing the benzthiazide in polyethylene glycol, stirring until the benzthiazide is dissolved, diluting with water, and adjusting the pH to between about 3 to 6. A benzyl alcohol preservative may be added if desired.
Inventors
- 👤 Samuel M. Fainberg
- 👤 Porfirio F. Perez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:30
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/12
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
33 words
A clear stable solution of benzthiazide suitable for parenteral or peroral administration which comprises benzthiazide dissolved in an effective amount of an aqueous polyalkalene glycol solution and having a pH suitable for injection.
Claim 2
Dependent Claim
33 words
A clear stable solution of benzthiazide suitable for parenteral or peroral administration which comprises benzthiazide dissolved in an effective amount of an aqueous polyalkalene glycol solution and having a pH suitable for injection.
Claim 3
Dependent Claim
15 words
The product of claim 1 wherein the solution contains an effective amount of a preservative.
Claim 4
Dependent Claim
22 words
The product of claim 2 wherein the preservative is selected from the group consisting of benzyl alcohol, sodium formaldehyde sulfoxylate and phenol.
Claim 5
Dependent Claim
24 words
The product of claim 1 wherein the polyalkalene glycol is present in the solution in an amount between about 45 to 85% by weight.
Claim 6
Dependent Claim
17 words
The product of claim 1 wherein the pH of the solution is between about 3 and 6.
Claim 7
Dependent Claim
34 words
The product of claim 5 wherein the pH is adjusted to between about 3 and 6 with an acid selected from the group consisting of sulfuric acid, hydrochloric acid, lactic acid, and citric acid.
Claim 8
Dependent Claim
21 words
The product of claim 1 wherein the polyalkalene glycol is a polyethylene glycol having an average molecular weight of about 300.
Claim 9
Independent Claim
46 words
A method of preparing a clear stable solution of benzthiazide suitable for parenteral or per oral administration comprising dissolving benzthiazide in an effective amount of an aqueous solution of polyalkalene glycol, to form a clear solution, and adjusting the solution to a pH suitable for injection.
Claim 10
Independent Claim
46 words
A method of preparing a clear stable solution of benzthiazide suitable for parenteral or per oral administration comprising dissolving benzthiazide in an effective amount of an aqueous solution of polyalkalene glycol, to form a clear solution, and adjusting the solution to a pH suitable for injection.
Claim 11
Dependent Claim
19 words
The method of claim 8 wherein the pH of the solution is adjusted to between about 3 and 6.
Claim 12
Dependent Claim
25 words
The method of claim 8 wherein the polyalkalene glycol in the final solvent is between about 45 and 85% by weight of the final solution.
Claim 13
Dependent Claim
17 words
The method of claim 8 wherein an effective amount of a preservative is added to the solution.
Claim 14
Dependent Claim
22 words
The method of claim 11 wherein the preservative is selected from the group consisting of benzyl alcohol, sodium formaldehyde sulfoxylate, and phenol.
Claim 15
Dependent Claim
23 words
The method of claim 8 wherein preservative is added at a level of up to about 5% by weight of the final solution.
Claim 16
Dependent Claim
21 words
The method of claim 8 wherein the polyalkalene glycol is a polyethylene glycol having an average molecular weight of about 300.
Claim 17
Dependent Claim
58 words
A clear stable solution of benzthiazide suitable for parenteral or peroral administration which comprised an effective amount of benzthiazide for dosage usage dissolved in an aqueous solution of polyalkalene glycol, the polyalkalene glycol being effective to dissolve benzthiazide in the aqueous solution and suitable for parenteral or peroral usage, the stable solution having a pH suitable for injection.
Claim 18
Dependent Claim
58 words
A clear stable solution of benzthiazide suitable for parenteral or peroral administration which comprised an effective amount of benzthiazide for dosage usage dissolved in an aqueous solution of polyalkalene glycol, the polyalkalene glycol being effective to dissolve benzthiazide in the aqueous solution and suitable for parenteral or peroral usage, the stable solution having a pH suitable for injection.
Claim 19
Dependent Claim
29 words
The product of claim 15 wherein the polyalkalene glycol is selected from the group consisting of polyethylene glycols and polypropylene glycols having an average molecular weight of about 300.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |