US4022814A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Iodine containing organic carbonates for use as radiographic agents
Assignee: Lafayette Pharmacal Inc
•
Filing: 1976-04-22
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Granted: 1977-05-10
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Expires: 1996-04-22
Abstract
Abstract Iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, for use as radiographic media in connection with such techniques as x-ray applications including myelography, salpingography, lymphography and bronchography. An effective quantity of iodinated organic carbonate provides x-ray contrast, and the compounds of the invention may be characterized generally as carbonates having the general formula ##STR1## wherein R represents an alkyl group having from 4 to 10 carbon atoms and R' represents an iodinated phenyl linked to the ester oxygen through an alkyl chain consisting of 1 to 3 carbon atoms.
Inventors
- 👤 Barry N. Newton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 01:39
CPC Classifications
C; C07; C07C; C07C29/00; C07C29/132; C07C29/136; C07C29/147; A; A61; A61K; A61K51/00; C07C57/00; C07C57/30; C07C57/42; C07C68/00; C07C68/02
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
105 words
A compound of the formula: ##STR27## wherein R 1 is a lower alkyl group consisting of straight or branched chains having from 4 to 10 carbon atoms, wherein R 2 is a lower alkylene chain linking the aromatic ring to the carbonate by 1 to 3 carbon atoms and having attached thereto a constituent selected from the group consisting of hydrogen and alkyl groups with 1 to 4 carbon atoms, X is selected from the group consisting of hydrogen and iodine, and Y is selected from the group consisting of hydrogen, iodine and amine when X is iodine and is iodine when X is hydrogen.
Claim 2
Dependent Claim
105 words
A compound of the formula: ##STR27## wherein R 1 is a lower alkyl group consisting of straight or branched chains having from 4 to 10 carbon atoms, wherein R 2 is a lower alkylene chain linking the aromatic ring to the carbonate by 1 to 3 carbon atoms and having attached thereto a constituent selected from the group consisting of hydrogen and alkyl groups with 1 to 4 carbon atoms, X is selected from the group consisting of hydrogen and iodine, and Y is selected from the group consisting of hydrogen, iodine and amine when X is iodine and is iodine when X is hydrogen.
Claim 3
Dependent Claim
12 words
The compound of claim 1 wherein said compound is p-iodobenzyl isobutyl carbonate.
Claim 4
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-amyl-p-iodobenzyl carbonate.
Claim 5
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-hexyl-p-iodobenzyl carbonate.
Claim 6
Dependent Claim
11 words
The compound of claim 1 wherein said compound is p-Iodobenzyl-4-methyl-2-pentyl carbonate.
Claim 7
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-octyl-p-iodobenzyl carbonate.
Claim 8
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-decyl-p-iodobenzyl carbonate.
Claim 9
Dependent Claim
11 words
The compound of claim 1 wherein said compound is 2-ethylhexyl-p-iodobenzyl carbonate.
Claim 10
Dependent Claim
11 words
The compound of claim 1 wherein said compound is 2-octyl-p-iodobenzyl carbonate.
Claim 11
Dependent Claim
11 words
The compound of claim 1 wherein said compound is 3-hexyl-p-iodobenzyl carbonate.
Claim 12
Dependent Claim
11 words
The compound of claim 1 wherein said compound is m-iodobenzyl-n-octyl carbonate.
Claim 13
Dependent Claim
11 words
The compound of claim 1 wherein said compound is 3,5-diiodobenzyl-n-hexyl carbonate.
Claim 14
Dependent Claim
11 words
The compound of claim 1 wherein said compound is 3-amino-2,4,6-triiodobenzyl-n-hexyl carbonate.
Claim 15
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-hexyl-p-iodo-sec-phenethyl carbonate.
Claim 16
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-hexyl-p-iodophenethyl carbonate.
Claim 17
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-hexyl-3-(p-iodophenyl)propyl carbonate.
Claim 18
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-hexyl-3-(p-iodophenyl)butyl carbonate.
Claim 19
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-hexyl-2-(p-iodobenzyl)butyl carbonate.
Claim 20
Dependent Claim
11 words
The compound of claim 1 wherein said compound is n-hexyl-2-(p-iodobenzyl)-n-hexyl carbonate.
References Cited (Backward Citations)
US3676486A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |