US4022805A
Expired / Lapsed
US
⏱️ 0.0 years remaining
8-Halo-dibenzofuran-3-acetic acids and certain esters thereof
Assignee: Hoffmann La Roche Inc
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Filing: 1975-02-10
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Granted: 1977-05-10
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Expires: 1995-02-10
Abstract
Abstract Dibenzofurans of the formula ##STR1## wherein R, R 1 and R 2 are as hereinafter described PREPARED, INTER ALIA, FROM THE CORRESPONDINGLY SUBSTITUTED PHENOL AND HALOKETOCYCLOHEXANE ARE DESCRIBED. The dibenzofurans of the invention are useful antiinflammatory, analgesic and anti-rheumatic agents.
Inventors
- 👤 Leo Berger
- 👤 Robert August Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 09:54
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/91; A; A61; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
73 words
A compound of the formula ##STR18## wherein R 1 is halogen; ##STR19## wherein B is hydroxy, lower alkoxy, or di-lower alkylamino-lower alkoxy, X is hydrogen and y is hydrogen or lower alkyl; and n is 1 when X and Y are different, an enatiomer; when B is hydroxy a salt thereof with a pharmaceutically acceptable base; or when B is di-lower alkylamino lower alkoxy, an addition salt thereof with a pharmaceutically acceptable acid.
Claim 2
Dependent Claim
73 words
A compound of the formula ##STR18## wherein R 1 is halogen; ##STR19## wherein B is hydroxy, lower alkoxy, or di-lower alkylamino-lower alkoxy, X is hydrogen and y is hydrogen or lower alkyl; and n is 1 when X and Y are different, an enatiomer; when B is hydroxy a salt thereof with a pharmaceutically acceptable base; or when B is di-lower alkylamino lower alkoxy, an addition salt thereof with a pharmaceutically acceptable acid.
Claim 3
Dependent Claim
11 words
A compound in accordance with claim 1, wherein B is hydroxy.
Claim 4
Dependent Claim
38 words
A compound of the formula ##STR20## wherein R' 1 is halogen, X is hydrogen and Y is hydrogen or lower alkyl; when X and Y are different, an enantiomer; or a salt thereof with a pharmaceutically acceptable base.
Claim 5
Dependent Claim
38 words
A compound of the formula ##STR20## wherein R' 1 is halogen, X is hydrogen and Y is hydrogen or lower alkyl; when X and Y are different, an enantiomer; or a salt thereof with a pharmaceutically acceptable base.
Claim 6
Dependent Claim
10 words
A compound in accordance with claim 3, racemic 8-chloro-α-methyldibenzofuran-3-acetic acid.
Claim 7
Dependent Claim
10 words
A compound in accordance with claim 4, (+) 8-chloro-α-methyl-dibenzofuran-3-acetic acid.
Claim 8
Dependent Claim
10 words
A compound in accordance with claim 4, (-) 8-chloro-α-methyldibenzofuran-3-acetic acid.
Claim 9
Dependent Claim
9 words
A compound in accordance with claim 3, 8-chloro-dibenzofuran-3-acetic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |