Prophylactic and therapeutic treatment of acne vulgaris utilizing lactamides and quaternary ammonium lactates

Claim 2

A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: as an active ingredient, a therapeutically effective amount of a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, lactic acid or lactic anhydride and a base selected from the group consisting ammonium hydroxide, an organic primary, secondary, or tertiary alkylamine, alkanol amine, diamine, dialkylamine, dialkanolamine, alkylalkanol amine, trialkylamine, trialkanol amine, dialkyl alkanol amine, and alkyl dialkanolamine wherein the alkyl or alkanol substituent has from 1 to 8 carbon atoms, in a pharmaceutically acceptable vehicle for topical application.

Claim 3

The composition of claim 1 wherein the active ingredient is present in a concentration of from 1 up to about 20 percent by volume of the total composition.

Claim 4

The composition of claim 1 wherein the active ingredient is present in a concentration of from 2 up to about 10 percent by volume of the total composition.

Claim 5

The composition of claim 1 wherein the active ingredient comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, dimethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, trimethylamine, triethylamine, triethanolamine, N-methyldiethanolamine, and triisopropylamine.

Claim 6

The composition of claim 1 wherein the active ingredient comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, propylamine, butylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, 1,3-diaminopropane, N-ethanolethylenediamine, dimethylamine, diethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, trimethylamine, triethylamine, triethanolamine, N-methyldiethanolamine, N,N-diethanolamine, N-ethyldiethanolamine, N-N-dimethylethanolamine, triisopropanolamine, and N-N-dioctylethanolamine.

Claim 7

The composition of claim 1 wherein the vehicle is at least one member selected from the group consisting of water, ethanol, and propylene glycol present therein in a concentration of up to 99, 70, and 30 percent, respectively.

Claim 8

The composition of claim 1 wherein the pH thereof is from about 3 to about 8.

Claim 9

The composition of claim 1 wherein the pH thereof is from about 3.5 to about 7.

Claim 10

A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 11 parts lactic acid, and 7 parts concentrated ammonium hydroxide solution admixed with 10 parts water, 50 parts ethanol, and 10 parts propylene glycol diluted with sufficient additional water to make 100 parts of said composition.

Claim 11

A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 11 parts lactic acid, and 7 parts concentrated ammonium hydroxide solution admixed with 10 parts water, 50 parts ethanol, and 10 parts propylene glycol diluted with sufficient additional water to make 100 parts of said composition.

Claim 12

A nonirritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 2.5 parts ethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 13

A nonirritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 2.5 parts ethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 14

A non-irritating composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 4 parts diethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 15

A non-irritating composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 4 parts diethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 16

A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 220 parts cetyl alcohol, 4 parts cholesterol, and 2 parts squalene; and a liquid comprising, in approximate parts by volume, 550 parts water, 100 parts propylene glycol, admixed with a product prepared, by reacting, in aqueous or alcoholic aqueous solution at room temperature, 50 parts lactic acid and 20 parts ethanolamine, said base and liquid being present in a weight-volume ratio of 276 grams of said base to 720 mls of said liquid.

Claim 17

A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 220 parts cetyl alcohol, 4 parts cholesterol, and 2 parts squalene; and a liquid comprising, in approximate parts by volume, 550 parts water, 100 parts propylene glycol, admixed with a product prepared, by reacting, in aqueous or alcoholic aqueous solution at room temperature, 50 parts lactic acid and 20 parts ethanolamine, said base and liquid being present in a weight-volume ratio of 276 grams of said base to 720 mls of said liquid.

Claim 18

A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene and 5 parts cholesterol; and a liquid comprising, in approximate parts by volume, 560 parts water, 20 parts mannitol and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 40 parts lactic acid, and 20 parts ethanolamine, said base and said liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.

Claim 19

A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene and 5 parts cholesterol; and a liquid comprising, in approximate parts by volume, 560 parts water, 20 parts mannitol and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 40 parts lactic acid, and 20 parts ethanolamine, said base and said liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.

Claim 20

A non-irritating therapeutic composition for treatment of the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts Tween 80, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene and 5 parts cholesterol; and a liquid comprising, in approximate parts by volume, 560 parts water, 100 parts propylene glycol, 40 parts lactic acid, 20 parts ethanolamine, and 20 parts mannitol, said base and said liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.

Claim 21

A non-irritating therapeutic composition for treatment of the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts Tween 80, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene and 5 parts cholesterol; and a liquid comprising, in approximate parts by volume, 560 parts water, 100 parts propylene glycol, 40 parts lactic acid, 20 parts ethanolamine, and 20 parts mannitol, said base and said liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.

Claim 22

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions, an effective amount of a composition comprising: a therapeutically effective amount of a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, lactic acid or lactic anhydride and a base selected from the group consisting of ammonium hydroxide, an organic primary, secondary, or tertiary alkylamine, alkanolamine, diamine, dialkylamine, dialkanolamine, alkylalkanolamine, trialkylamine, trialkanol amine, Dialkyl alkanol amine, or alkyl dialkanolamine wherein the alkyl or alkanol substituent has from 1 to 8 carbon atoms, in a pharmaceutically acceptable vehicle.

Claim 23

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions, an effective amount of a composition comprising: a therapeutically effective amount of a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, lactic acid or lactic anhydride and a base selected from the group consisting of ammonium hydroxide, an organic primary, secondary, or tertiary alkylamine, alkanolamine, diamine, dialkylamine, dialkanolamine, alkylalkanolamine, trialkylamine, trialkanol amine, Dialkyl alkanol amine, or alkyl dialkanolamine wherein the alkyl or alkanol substituent has from 1 to 8 carbon atoms, in a pharmaceutically acceptable vehicle.

Claim 24

The method of claim 15 wherein the reaction product is present in a concentration of from 1 up to about 20 percent by volume of the total composition.

Claim 25

The method of claim 15 wherein the reaction product is present in a concentration of from 2 up to about 10 percent by volume of the total composition.

Claim 26

The method of claim 15 wherein the product comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, dimethylamine, diethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, triethylamine, triethanolamine, N-methyldiethanolamine, and triisopropylamine.

Claim 27

The method of claim 15 wherein the product comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, propylamine, butylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, 1,3-diaminopropane, N-ethanolethylenediamine, dimethylamine, diethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, trimethylamine, triethylamine, triethanolamine, N-methyldiethanolamine, N,N-diethanolamine, N-ethyldiethanolamine, N-N-dimethylethanolamine, triisopropanolamine, and N,N-dioctylethanolamine.

Claim 28

The method of claim 15 wherein the vehicle is at least one member selected from the group consisting of water, ethanol, and propylene glycol present therein in a concentration of up to 99, 70, and 30 percent, respectively.

Claim 29

The method of claim 15 wherein the pH thereof is from about 3 to about 8.

Claim 30

The method of claim 15 wherein the pH thereof is from about 3.5 to about 7.

Claim 31

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of the composition comprising in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 11 parts lactic acid, and 7 parts concentrated ammonium hydroxide admixed with 10 parts water, 50 parts ethanol, and 10 parts propylene glycol, diluted with sufficient additional water to make 100 parts of said composition.

Claim 32

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of the composition comprising in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 11 parts lactic acid, and 7 parts concentrated ammonium hydroxide admixed with 10 parts water, 50 parts ethanol, and 10 parts propylene glycol, diluted with sufficient additional water to make 100 parts of said composition.

Claim 33

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 2.5 parts ethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 34

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 2.5 parts ethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 35

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 4 parts diethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 36

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 4 parts diethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

Claim 37

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture: an ointment base comprising in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 220 parts cetyl alcohol, 4 parts cholesterol, and 2 parts squalene; and a liquid comprising in approximate parts by volume, 550 parts water, and 1-0 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 50 parts lactic acid, and 20 parts ethanolamine, said base and liquid being present in a weight-volume ratio of 276 grams of said base to 720 mls of said liquid.

Claim 38

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture: an ointment base comprising in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 220 parts cetyl alcohol, 4 parts cholesterol, and 2 parts squalene; and a liquid comprising in approximate parts by volume, 550 parts water, and 1-0 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 50 parts lactic acid, and 20 parts ethanolamine, said base and liquid being present in a weight-volume ratio of 276 grams of said base to 720 mls of said liquid.

Claim 39

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, and 5 parts squalene, and a liquid comprising, in approximate parts by volume, 570 parts water, 20 parts mannitol and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 30 parts lactic acid and 25 parts triethanolamine, said base and said liquid being present in a weight-volume ratio of 255 grams base to 745 mls liquid.

Claim 40

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, and 5 parts squalene, and a liquid comprising, in approximate parts by volume, 570 parts water, 20 parts mannitol and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 30 parts lactic acid and 25 parts triethanolamine, said base and said liquid being present in a weight-volume ratio of 255 grams base to 745 mls liquid.

Claim 41

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture, an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene, and 5 parts cholesterol, and a liquid comprising, in approximate parts by volume, 560 parts water, 20 parts mannitol, and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 40 parts lactic acid, and 20 parts ethanolamine, said base and liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.

Claim 42

A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture, an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene, and 5 parts cholesterol, and a liquid comprising, in approximate parts by volume, 560 parts water, 20 parts mannitol, and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 40 parts lactic acid, and 20 parts ethanolamine, said base and liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.