US4021558A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents
Assignee: Boehringer Ingelheim GmbH
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Filing: 1976-01-22
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Granted: 1977-05-03
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Expires: 1996-01-22
Abstract
Abstract Compounds of the formula <IMAGE> <IMAGE> wherein R1 is hydrogen, halogen, methoxy or methylthio, R2 is hydrogen or methoxy, N IS 2 OR 3, R3 is hydrogen or methyl, and R4 and R5, which may be identical to or different from each other, are each hydrogen or methoxy, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, sedatives, antiarrhythmics and bradycardiacs.
Inventors
- 👤 Eberhard Kutter
- 👤 Volkard Austel
- 👤 Wolfgang Eberlein
- 👤 Joachim Heider
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:46
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/22; C07D217/24
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
52 words
A compound of the formula ##STR10## wherein R 1 is hydrogen, halogen, methoxy or methylthio, R 2 is hydrogen or methoxy, n is 2 or 3, R 3 is hydrogen or methyl, and R 4 and R 5 are each hydrogen or methoxy, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
52 words
A compound of the formula ##STR10## wherein R 1 is hydrogen, halogen, methoxy or methylthio, R 2 is hydrogen or methoxy, n is 2 or 3, R 3 is hydrogen or methyl, and R 4 and R 5 are each hydrogen or methoxy, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
18 words
A compound of claim 1, which is 1-[4,4-dimeth-yl-7 -methoxy-1,3-dioxo-(2H,4H)-isoquinoline-2-yl]-3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-propane or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
32 words
The method of lowering the blood pressure of a warm-blooded animal in need of such treatment, which comprises administering to said animal an effective hypotensive amount of a compound of claim 1.
Claim 5
Dependent Claim
24 words
A hypotensive pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective hypotensive amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-02 | 1980-11-01 | 1981-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-02 | 1984-11-01 | 1985-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-02 | 1988-11-01 | 1989-05-03 | $7700.00 | Window Closed / Lapsed |