US4018222A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Syringe containing frozen vaccine
Assignee: Merck and Co Inc
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Filing: 1975-05-13
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Granted: 1977-04-19
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Expires: 1995-05-13
Abstract
Abstract Vaccine delivery system wherein an aqueous vaccine diluted to human dosage concentration is loaded into presterilized single dosage syringes having a squeezable body portion and wherein a plurality of these syringes are sealed inside a bag and the contents of the syringes are frozen to preserve the titer of the vaccine.
Inventors
- 👤 William J. McAleer
- 👤 Maurice R. Hilleman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:52
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/178; A61M5/28; A61M5/281; A61M5/282; A61M5/285; A61M5/288
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
127 words
A vaccine delivery system suitable for human administration comprising a single dosage hypodermic syringe having a container portion made of a plastic material which is resiliently flexible at room temperature and a needle portion comprising a hollow sharp needle extending from the plastic container portion to convey fluids from within the container out through the tip of the needle when the needle is inserted under the skin and the container is squeezed, an aqueous vaccine diluted to a concentration suitable for human administration and sealed within the container, the vaccine being in the frozen state at a temperature of from about -10° C to about -20° C, whereby the vaccine is preserved for storage and shipment and the syringe is protected from leakage during storage and shipment.
Claim 2
Dependent Claim
127 words
A vaccine delivery system suitable for human administration comprising a single dosage hypodermic syringe having a container portion made of a plastic material which is resiliently flexible at room temperature and a needle portion comprising a hollow sharp needle extending from the plastic container portion to convey fluids from within the container out through the tip of the needle when the needle is inserted under the skin and the container is squeezed, an aqueous vaccine diluted to a concentration suitable for human administration and sealed within the container, the vaccine being in the frozen state at a temperature of from about -10° C to about -20° C, whereby the vaccine is preserved for storage and shipment and the syringe is protected from leakage during storage and shipment.
Claim 3
Dependent Claim
18 words
A vaccine delivery system according to claim 1 wherein said container portion is composed of low density polyethylene.
Claim 4
Dependent Claim
95 words
In combination, a plurality of hypodermic syringes each comprising a tubular container portion of plastic material which is resiliently flexible at room temperature and a needle portion comprising a hollow sharp needle extending out from the container portion, a single dosage of an aqueous vaccine, diluted to a concentration suitable for human administration, contained in each tubular container portion and sealed therein, said vaccine being frozen at a temperature of from about -10° C to about -20° C and a gas and light impervious bag enveloping said plurality of syringes and sealing said syringes therein.
Claim 5
Dependent Claim
95 words
In combination, a plurality of hypodermic syringes each comprising a tubular container portion of plastic material which is resiliently flexible at room temperature and a needle portion comprising a hollow sharp needle extending out from the container portion, a single dosage of an aqueous vaccine, diluted to a concentration suitable for human administration, contained in each tubular container portion and sealed therein, said vaccine being frozen at a temperature of from about -10° C to about -20° C and a gas and light impervious bag enveloping said plurality of syringes and sealing said syringes therein.
Claim 6
Dependent Claim
17 words
A combination according to claim 3 wherein said gas and light impervious bag is of aluminum foil.
Claim 7
Dependent Claim
21 words
A combination according to claim 3 wherein said syringes include removable dust covers enveloping the outer end of their needle portion.
Claim 8
Independent Claim
116 words
A method of preparing vaccine for delivery storage and administration comprising the steps of filling tubular flexible syringes having a plastic container portion which is resiliently flexible at room temperature and a hollow sharp needle extending from the plastic container with an aqueous vaccine diluted to human administration concentration, each syringe containing a single dose of the vaccine, sealing the syringes closed, enveloping and sealing a plurality of the filled and sealed syringes inside a gas and light impervious bag, subjecting the filled bag to a temperature low enough to freeze the vaccine and maintaining the vaccine in the bag during storage and shipment at a temperature of from about -10° C to about -20° C.
Claim 9
Independent Claim
116 words
A method of preparing vaccine for delivery storage and administration comprising the steps of filling tubular flexible syringes having a plastic container portion which is resiliently flexible at room temperature and a hollow sharp needle extending from the plastic container with an aqueous vaccine diluted to human administration concentration, each syringe containing a single dose of the vaccine, sealing the syringes closed, enveloping and sealing a plurality of the filled and sealed syringes inside a gas and light impervious bag, subjecting the filled bag to a temperature low enough to freeze the vaccine and maintaining the vaccine in the bag during storage and shipment at a temperature of from about -10° C to about -20° C.
Claim 10
Dependent Claim
22 words
A method according to claim 6 further including the step of subjecting the syringe to an ethylene oxide atmosphere prior to filling.
Claim 11
Dependent Claim
24 words
A method according to claim 7 further including the step of subjecting the syringe to a vacuum to purge the syringe of ethylene oxide.
Claim 12
Dependent Claim
29 words
A method according to claim 6 wherein said filled bag is subjected to a temperature low enough to freeze the vaccine by placing said bag in liquid nitrogen vapors.
Claim 13
Dependent Claim
20 words
A method according to claim 6 wherein the bag is maintained at said temperature by placing it in dry ice.
Claim 14
Dependent Claim
17 words
A method according to claim 6 wherein the bag is maintained at said temperature by mechanical refrigeration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-18 | 1980-10-18 | 1981-04-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-18 | 1984-10-18 | 1985-04-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-18 | 1988-10-18 | 1989-04-19 | $7700.00 | Window Closed / Lapsed |