Patent US4573117A successfully refreshed from Google Patents.
US4017616A
Expired / Lapsed
US
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Parenteral benzodiazepine compositions
Assignee: Wyeth LLC
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Filing: 1973-04-13
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Granted: 1977-04-12
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Expires: 1993-04-13
Abstract
Abstract Stable, non-aqueous parenteral dosage forms of benzodiazepine compounds comprise from about 10% to about 65% polyethylene glycol, from about 35% to about 90% propylene glycol, from 0% to about 10% benzyl alcohol, and 1 mg. to 15 mg. of benzodiazepine compound per ml.
Inventors
- 👤 Eloy A. Gomez
- 👤 Howard J. Levin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
75 words
A parenterally acceptable composition comprising from about 10% to about 65% polyethylene glycol, from about 35% to about 90% propylene glycol, from 0% to about 10% benzyl alcohol, and, per ml. of the above solution, from about 1 mg. to about 15 mg. of a benzodiazepine compound of the formula: ##STR2##wherein R 1 and R 2 are independently hydrogen or methyl, and R 3 is hydrogen or chlorine, said composition being substantially free of water.
Claim 2
Dependent Claim
75 words
A parenterally acceptable composition comprising from about 10% to about 65% polyethylene glycol, from about 35% to about 90% propylene glycol, from 0% to about 10% benzyl alcohol, and, per ml. of the above solution, from about 1 mg. to about 15 mg. of a benzodiazepine compound of the formula: ##STR2##wherein R 1 and R 2 are independently hydrogen or methyl, and R 3 is hydrogen or chlorine, said composition being substantially free of water.
Claim 3
Dependent Claim
19 words
A composition according to claim 1 wherein R 1 and R 2 are hydrogen, and R 3 is chlorine.
Claim 4
Dependent Claim
20 words
A composition according to claim 1 wherein R 1 is methyl, R 2 is methyl, and R 3 is chlorine.
Claim 5
Dependent Claim
29 words
A composition according to claim 2 wherein the polyethylene glycol concentration is about 18%, the propylene glycol concentration is about 80%, and the benzyl alcohol concentration is about 2%.
Claim 6
Dependent Claim
22 words
A composition according to claim 2 wherein the polyethylene glycol concentration is about 20%, and the propylene glycol concentration is about 80%.
Claim 7
Dependent Claim
22 words
A composition according to claim 3 wherein the polyethylene glycol concentration is about 50% and the propylene glycol concentration is about 50%.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |