US4017595A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone-seeking indium-113m or indium-111 organic phosphonate complexes
Assignee: Research Corp
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Filing: 1975-08-28
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Granted: 1977-04-12
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Expires: 1995-08-28
Abstract
Abstract The invention relates to bone-seeking compositions suitable for use as skeletal imaging agents comprising complexes of Indium-113m or Indium-111 with various organic phosphonates, methods of preparation thereof, compositions for skeletal imaging and methods of skeletal imaging comprising the administration of these phosphonates.
Inventors
- 👤 Gopal Subramanian
- 👤 John Gilmour McAfee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 15:51
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0489; A61K2123/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
33 words
A bone-seeking skeletal imaging agent comprising a complex of Indium-113m or Indium-111 with ethylene diamine tetra (methylene phosphonic) acid, diethylene triamine penta(methylene phosphonic) acid, or a salt thereof with a pharmaceutically acceptable cation.
Claim 2
Dependent Claim
33 words
A bone-seeking skeletal imaging agent comprising a complex of Indium-113m or Indium-111 with ethylene diamine tetra (methylene phosphonic) acid, diethylene triamine penta(methylene phosphonic) acid, or a salt thereof with a pharmaceutically acceptable cation.
Claim 3
Dependent Claim
15 words
A bone-seeking agent according to claim 1 comprising an Indium-113m-ethylene diamine tetra (methylene phosphonate) complex.
Claim 4
Dependent Claim
14 words
A bone-seeking agent according to claim 1 comprising an Indium-113m-diethylene triamine penta(methylene phosphonate) complex.
Claim 5
Dependent Claim
14 words
A bone-seeking agent according to claim 1 comprising an Indium-111-ethylene diamine tetra(methylene phosphonate) complex.
Claim 6
Dependent Claim
14 words
A bone-seeking agent according to claim 1 comprising an Indium-111-diethylene triamine penta(methylene phosphonate) complex.
Claim 7
Dependent Claim
17 words
A bone-seeking composition comprising a solution adapted for intravenous administration containing a complex according to claim 1.
Claim 8
Dependent Claim
14 words
The composition of claim 6 in unit dosage form containing 5-20 mCi of radioactivity.
Claim 9
Dependent Claim
40 words
A method of preparing the skeletal imaging agent of claim 1 comprising admixing in aqueous solution Indium-113m or Indium-111 and ethylene diamine tetra (methylene phosphonic) acid, diethylene triamine penta(methylene phosphonic) acid or a salt thereof with a pharmaceutically acceptable cation.
Claim 10
Dependent Claim
13 words
The method of claim 8 wherein said cation is sodium, potassium or ammonium.
Claim 11
Dependent Claim
23 words
A method of skeletal-imaging which includes the intravenous administration of a solution adapted for intravenous administration containing a complex according to claim 1.
Claim 12
Dependent Claim
23 words
A method of skeletal-imaging which includes the intravenous administration of a solution adapted for intravenous administration containing a complex according to claim 2.
Claim 13
Dependent Claim
23 words
A method of skeletal-imaging which includes the intravenous administration of a solution adapted for intravenous administration containing a complex according to claim 3.
Claim 14
Dependent Claim
23 words
A method of skeletal-imaging which includes the intravenous administration of a solution adapted for intravenous administration containing a complex according to claim 4.
Claim 15
Dependent Claim
23 words
A method of skeletal-imaging which includes the intravenous administration of a solution adapted for intravenous administration containing a complex according to claim 5.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |