US4017471A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immunological compounds
Assignee: GD Searle LLC
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Filing: 1975-09-15
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Granted: 1977-04-12
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Expires: 1995-09-15
Abstract
Abstract The present invention relates to an antitumor agent comprising p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride bound to a tumor specific antibody by peptide bonds. The antitumor agent of the present invention is prepared by reacting a cytotoxic agent, p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride with a tumor specific antibody in the presence of a water soluble carbodiimide such as 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and thereby forming a peptide bond between the cytotoxic agent and the tumor specific antibody.
Inventors
- 👤 David Allen Lewis Davies
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:39
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K31/13; A61K31/135; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6889; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
21 words
An antitumor agent comprising p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride as a cytotoxic agent bound to a tumor specific antibody by peptide bonds.
Claim 2
Dependent Claim
21 words
An antitumor agent comprising p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride as a cytotoxic agent bound to a tumor specific antibody by peptide bonds.
Claim 3
Dependent Claim
19 words
An antitumor agent according to claim 1 having 5-15 molecules of cytotoxic agent per molecule of tumor specific antibody.
Claim 4
Dependent Claim
19 words
An antitumor agent according to claim 1 comprising p-di(2-chloroethyl)amino-L-phenylalamine bound to antibodies specific against EL4 lymphoma by peptide bonds.
Claim 5
Dependent Claim
19 words
An antitumor agent according to claim 1 comprising N,N-bis(2-chloroethyl)p-phenylenediamine bound to antibodies specific against EL4 lymphoma by peptide bonds.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |