Patent AU217758B2 successfully refreshed from Google Patents.
US4017359A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Production of non-antigenic attenuated viruses
Assignee: Bayer AG
•
Filing: 1974-06-24
•
Granted: 1977-04-12
•
Expires: 1994-06-24
Abstract
Abstract There is disclosed novel non-antigenic attenuated viruses which non-specifically stimulate the natural defense mechanism of a host organism with a detectable non-specific induction of interferon; to methods for their production and to their use for the prophylaxis and treatment of viral and bacterial infections in human and veterinary medicine.
Inventors
- 👤 Otto-Christian Straub
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 21:25
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61K; A61K35/00; A61K35/66; A61K35/76; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16711; C12N2710/16732; C12N2710/16761; C12N2710/16764; Y; Y10; Y10S; Y10S435/00; Y10S435/811
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
87 words
A method of producing an attenuated virus capable of stimulating the natural defense mechanism of a host organism with a detectable non-specific induction of interferon wihtout antigenic effect which comprises passing a virus through a plurality of at least 300 tissue cultures to achieve a degree of attenuation such that antigenic effect cannot be detected in the presence of a detectable non-specific induction of interferon in said organism, wherein said virus is AUJESZKY/pseudo-rabies virus, Influenza virus A1, Influenza virus A1--strain FM1, AUJESZKY/pseudo-rabies virus--strain S/T, or IPV virus.
Claim 2
Independent Claim
87 words
A method of producing an attenuated virus capable of stimulating the natural defense mechanism of a host organism with a detectable non-specific induction of interferon wihtout antigenic effect which comprises passing a virus through a plurality of at least 300 tissue cultures to achieve a degree of attenuation such that antigenic effect cannot be detected in the presence of a detectable non-specific induction of interferon in said organism, wherein said virus is AUJESZKY/pseudo-rabies virus, Influenza virus A1, Influenza virus A1--strain FM1, AUJESZKY/pseudo-rabies virus--strain S/T, or IPV virus.
Claim 3
Dependent Claim
25 words
The method of claim 1 in which each tissue culture passage is of cattle tissue at a temperature in the range of from 36°-40° C.
Claim 4
Dependent Claim
24 words
The method of claim 2 wherein the tissue culture-to-tissue culture transfer takes place over a period of time of from 12 to 100 hours.
Claim 5
Dependent Claim
15 words
The method claim 2 in which the tissue is calf kidney, suprarenal or testicular tissue.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |