US4017192A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Optical analysis of biomedical specimens
Assignee: NEOTEC Corp A CORP OF DE
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Filing: 1975-02-06
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Granted: 1977-04-12
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Expires: 1995-02-06
Abstract
Abstract A technique for automatic detection of abnormalities, particularly pathology, in biomedical specimens. Light transmittance or reflectance data over a large number of wavelengths for numerous samples are correlated mathematically with conventional clinical results to select test wavelengths and constants for a correlation equation. Optical instrumentation with an analog or digital computer applies the resulting correlation equation to the spectral data on a given specimen at the test wavelengths to determine quantitatively the presence of the abnormality.
Inventors
- 👤 Robert D. Rosenthal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:43
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/0059; G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/31; G01N21/314; G01J; G01J1/00; G01J1/10; G01J1/16; G01J1/18; G01J2001/182; G01J3/00; G01J3/12; G01J2003/1226; G01J2003/1243; G01N21/35; G01N21/59
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
57 words
A method of detecting pathological abnormality in a multicellular bulk biomedical specimen comprising the steps of recording and analyzing light absorption spectrum data of the multicellular bulk specimen in accordance with a mathematical expression which correlates the spectrum data of a multiplicity of corresponding biomedical samples with the results of typing of said samples by clinical pathology.
Claim 2
Independent Claim
57 words
A method of detecting pathological abnormality in a multicellular bulk biomedical specimen comprising the steps of recording and analyzing light absorption spectrum data of the multicellular bulk specimen in accordance with a mathematical expression which correlates the spectrum data of a multiplicity of corresponding biomedical samples with the results of typing of said samples by clinical pathology.
Claim 3
Independent Claim
91 words
A method of detecting the presence of a pathological abnormality in a multicellular bulk biomedical specimen, comprising the steps of illuminating the multicellular bulk specimen sequentially with a plurality of difference light wavelengths, recording selected light absorption dependent values within the sample's light output spectrum, computing the value of a mathematical function of said selected absorption-dependent values, said mathematical function being selected to produce a computed value which correlates with the presence or absence of said pathological abnormality, and comparing the level of the computed value to a predetermined screening level.
Claim 4
Independent Claim
91 words
A method of detecting the presence of a pathological abnormality in a multicellular bulk biomedical specimen, comprising the steps of illuminating the multicellular bulk specimen sequentially with a plurality of difference light wavelengths, recording selected light absorption dependent values within the sample's light output spectrum, computing the value of a mathematical function of said selected absorption-dependent values, said mathematical function being selected to produce a computed value which correlates with the presence or absence of said pathological abnormality, and comparing the level of the computed value to a predetermined screening level.
Claim 5
Dependent Claim
13 words
The method of claim 2, wherein said absorption-dependent values are light transmittance-dependent values.
Claim 6
Dependent Claim
16 words
The method of claim 3, wherein said transmittance-dependent values are optical density values at selected wavelengths.
Claim 7
Dependent Claim
29 words
The method of claim 3, wherein each said transmittance-dependent value is the ratio of a derivative of the transmittivity of the specimen and absolute transmissivity at a selected wavelength.
Claim 8
Dependent Claim
17 words
The method of claim 2, wherein said pathological abnormality is malignancy and said specimen is animal tissue.
Claim 9
Dependent Claim
29 words
The method of claim 6, werein each said absorption-dependent value is the ratio of a derivative of the transmissivity of the specimen and absolute transmissivity at a selected wavelength.
Claim 10
Dependent Claim
13 words
The method of claim 6, wherein said animal tissue is human cervical tissue.
Claim 11
Dependent Claim
13 words
The method of claim 6, wherein said animal tissue is rat liver tissue.
Claim 12
Dependent Claim
13 words
The method of claim 6, wherein said animal tissue is mouse bladder tissue.
Claim 13
Dependent Claim
15 words
The method of claim 6, wherein said animal tissue is human female reproductive organ tissue.
Claim 14
Dependent Claim
18 words
The method of claim 2, wherein said specimen is serum and said pathological abnormality therein is bacterial contamination.
Claim 15
Dependent Claim
14 words
The method of claim 2, wherein said wavelengths are all greater than 5,000 A.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |