US4016877A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fibrous collagen derived web having hemostatic and wound sealing properties
Assignee: MedChem Products Inc
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Filing: 1976-02-23
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Granted: 1977-04-12
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Expires: 1996-02-23
Abstract
Abstract Non-woven, liquid-laid, fibrous web having hemostatic and adhesive properties adapted to seal a wound formed of fibers consisting of an ionizable, water-insoluble, partial salt of collagen, the web when placed on a saline solution disintegrating completely and the fibers self disperse. The web is formed from a slurry of the fibers in a water-miscible organic liquid such as ethanol containing a small proportion of an ionizable acid.
Inventors
- 👤 Mamerto M. Cruz, Jr.
- 👤 John H. Tenery
- 👤 LaVerne C. Tressler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:18
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61P; A61P7/00; A61P7/04; A61L2400/00; A61L2400/04; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S602/00; Y10S602/90
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
120 words
The method of forming a hemostat-adhesive, liquid-laid, non-woven web dressing for severed biological surfaces from hemostat-adhesive fibers consisting of an ionizable, water-insoluble, partial acid salt of collagen, the partial acid salt of collagen containing from about 50 to 90% of the theoretical stoichiometric amount of ionizable acid, the steps of preparing a slurry of the fibers in a water-miscible organic liquid containing a small proportion of an ionizable acid, the proportion of acid being sufficient to prevent leaching of acid from the partial salt of collagen, sheeting the fibers to form a web, removing excess liquid from the web, subjecting the web to a uniform pressure between 7 and 70,3 gm. per sq. cm. and thereafter freeze drying the web.
Claim 2
Independent Claim
120 words
The method of forming a hemostat-adhesive, liquid-laid, non-woven web dressing for severed biological surfaces from hemostat-adhesive fibers consisting of an ionizable, water-insoluble, partial acid salt of collagen, the partial acid salt of collagen containing from about 50 to 90% of the theoretical stoichiometric amount of ionizable acid, the steps of preparing a slurry of the fibers in a water-miscible organic liquid containing a small proportion of an ionizable acid, the proportion of acid being sufficient to prevent leaching of acid from the partial salt of collagen, sheeting the fibers to form a web, removing excess liquid from the web, subjecting the web to a uniform pressure between 7 and 70,3 gm. per sq. cm. and thereafter freeze drying the web.
Claim 3
Dependent Claim
26 words
The method as defined in claim 1 wherein the fibers consist of a partial hydrogen chloride salt of collagen and the ionizable acid is hydrochloric acid.
Claim 4
Dependent Claim
20 words
The method as defined in claim 1 wherein the organic liquid is ethanol and contains not more than 5% water.
Claim 5
Dependent Claim
38 words
The method as defined in claim 1 wherein the fibers consist of a partial hydrogen chloride salt of collagen, the organic liquid is ethanol and contains not more than 5% water and the ionizable acid is hydrochloric acid.
Claim 6
Dependent Claim
85 words
The method as defined in claim 1 wherein the fibers consist of a partial hydrogen chloride salt of collagen containing about 84% of the theoretical stoichiometric amount of hydrogen chloride, the organic liquid is ethanol, the ionizable acid is hydrochloric acid in an amount of about 0.3 gm. of concentrated hydrochloric acid (37.5% of HCL) per 13.62 kg. of ethanol based upon a fiber concentration of 0.3% to 0.5%, dry basis and the web is subjected to a pressure of 20 to 35 gm./sq. cm.
Claim 7
Dependent Claim
107 words
A hemostat-adhesive web dressing for severed biological surfaces comprising a liquid-laid, non-woven web having hemostat-adhesive properties and formed of hemostatic-adhesive fibers consisting of an ionizable, water-insoluble, partial salt of collagen, the web having a water holding capacity of from about 20 to about 25 gm. of water per gm. of web, based upon a basis weight of about 300 gm. per sq. m., and being further characterized in that when placed on a 0.9% saline solution disintegrates completely and the fibers self disperse immediately upon contacting the solution, the partial salt of collagen containing from about 50 to 90% of the theoretical stoichiometric amount of ionizable acid.
Claim 8
Dependent Claim
107 words
A hemostat-adhesive web dressing for severed biological surfaces comprising a liquid-laid, non-woven web having hemostat-adhesive properties and formed of hemostatic-adhesive fibers consisting of an ionizable, water-insoluble, partial salt of collagen, the web having a water holding capacity of from about 20 to about 25 gm. of water per gm. of web, based upon a basis weight of about 300 gm. per sq. m., and being further characterized in that when placed on a 0.9% saline solution disintegrates completely and the fibers self disperse immediately upon contacting the solution, the partial salt of collagen containing from about 50 to 90% of the theoretical stoichiometric amount of ionizable acid.
Claim 9
Dependent Claim
21 words
The hemostat-adhesive web dressing as deined in claim 6 wherin the fibers consist of a partial hydrogen chloride salt of collagen.
Claim 10
Dependent Claim
34 words
The hemostat-adhesive web dressing as defined in claim 6 wherein the fibers consist of a partial hydrogen chloride salt of collagen containing from 50% to 90% of the theoretical stoichiometric amount of hydrogen chloride.
Claim 11
Dependent Claim
32 words
The hemostat-adhesive web dressing as defined in claim 6 wherein the fibers consist of a partial hydrogen chloride salt of collagen containing about 84% of the theoretical stoichiometric amount of hydrogen chloride.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |