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US4013776A
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Phenylsulphinyl-amidine derivatives
Assignee: Cephalon France SAS
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Filing: 1975-09-29
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Granted: 1977-03-22
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Expires: 1995-09-29
Abstract
Abstract Phenylsulphinyl derivatives of the formula ##STR1## in which R 1 represents hydrogen or one or more identical or different substituents, Alk represents a C 2 -C 4 hydrocarbon radical with a linear or branched chain, and A represents C(=NH)NH 2 , C(=NH)NHOH, C(=O)NHOH, or ##STR2## where Z is CH 2 CH 2 or CH 2 CH 2 CH 2 and R is H, CH 2 COOH, CH(CH 3 )COOH or C(CH 3 ) 2 COOH, and their addition salts, have interesting therapeutic properties on the central nervous system as anxiolytic agents and/or analgesic and anti-inflammatory agents.
Inventors
- 👤 Victor Lafon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:40
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; A; A61; A61P; A61P25/00; A61P25/04; A61P29/00; A61P3/00; A61P3/06; A61P7/00; A61P7/02; A61P9/00; A61P9/08; A61P9/10; C07C; C07C259/00; C07C259/12; C07C259/14; C07C317/00; C07C317/44; C07C43/00; C07C43/02; C07C43/257; C07C43/295; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07C59/70; C07D233/00; C07D233/04; C07D233/20; C07D233/22; C07D295/16; C07D295/20; C07D295/205
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
58 words
A phenylsulphinyl derivative of the formula: ##STR27## in which R 1 is at least one substituent selected from the group consisting of H, F, Cl, Br, CF 3 , C 1 -C 4 alkyl, C 1 -C 4 alkoxy and NO 2 and Alk represents a C 2 -C 4 hydrocarbon radical having a linear or branched chain.
Claim 2
Dependent Claim
58 words
A phenylsulphinyl derivative of the formula: ##STR27## in which R 1 is at least one substituent selected from the group consisting of H, F, Cl, Br, CF 3 , C 1 -C 4 alkyl, C 1 -C 4 alkoxy and NO 2 and Alk represents a C 2 -C 4 hydrocarbon radical having a linear or branched chain.
Claim 3
Dependent Claim
45 words
A phenylsulphinyl derivative as claimed in claim 1 wherein R 1 is selected from the group consisting of H, F, Cl and CF 3 and Alk is selected from the group consisting of CH 2 CH 2 and CH 2 CH 2 CH 2 .
Claim 4
Dependent Claim
12 words
A phenylsulphinyl derivative as claimed in claim 1 which is 4-phenylsulphinyl-butyrohydroxamic acid.
Claim 5
Dependent Claim
12 words
A phenylsulphinyl derivative as claimed in claim 1 which is 3-(p-fluorophenylsulphinyl)-propiohydroxamic acid.
Claim 6
Dependent Claim
12 words
A phenylsulphinyl derivative as claimed in claim 1 which is 4-(p-chlorophenylsulphinyl)-butyrohydroxamic acid.
Claim 7
Dependent Claim
12 words
A phenylsulphinyl derivative as claimed in claim 1 which is 4-(p-fluorophenylsulphinyl)-butyrohydroxamic acid.
Claim 8
Dependent Claim
25 words
A therapeutic composition comprising a pharmaceutically effective amount of at least one compound as claimed in claim 1 in combination with a physiologically acceptable excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-21 | 1980-09-20 | 1981-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-21 | 1984-09-20 | 1985-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-21 | 1988-09-20 | 1989-03-22 | $7700.00 | Window Closed / Lapsed |