16,16-Dimethyl 9-oxo-11α-hydroxymethyl-15ε-hydroxyprosta-5(cis), 13(trans)-dienoic acid derivatives and process for the preparation thereof
Abstract
Abstract Prostanoic acid derivatives having the formula ##STR1## wherein A represents a straight or branched alkylene group having from one to 5 carbon atoms, R 1 represents a straight or branched alkyl group having from 4 to 10 carbon atoms and R 2 represents hydrogen atom or a straight or branched alkyl group having from one to 6 carbon atoms and pharmaceutically acceptable salts thereof. The compounds are useful as oxytocic agents and agents inhibiting the secretion of gastric acid and may be prepared by oxidizing a compound having the formula ##STR2## wherein A, R 1 and R 2 are the same as above, R 3 and R 4 are the same or different and each represents a protecting group for the hydroxyl group to give a compound having the formula ##STR3## wherein A, R 1 , R 2 , R 3 and R 4 are the same as above, removing the hydroxyl-protecting group from the latter compound and, if appropriate, salifying the product thus obtained.
Inventors
- 👤 Kiyoshi Sakai
- 👤 Osamu Oda
- 👤 Takashi Yusa
- 👤 Mitsuo Yamazaki
- 👤 Masaaki Sasaki
- 👤 Kazuhiko Sasagawa
Bibliographic Details
Claims Analysis
Total Claims: 8References Cited (Backward Citations)
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